TYRO3

Gene Symbol	TYRO3
Entrez Gene	7301
Alt Symbol	BYK, Dtk, Etk-2, RSE, Rek, Sky, Tif
Species	Human
Gene Type	protein-coding
Description	TYRO3 protein tyrosine kinase
Other Description	tyrosine-protein kinase DTK|tyrosine-protein kinase RSE|tyrosine-protein kinase SKY|tyrosine-protein kinase TIF|tyrosine-protein kinase byk|tyrosine-protein kinase receptor TYRO3
Swissprots	Q86VR3 O14953 Q06418
Accessions	BAA05134 EAW92506 EAW92507 EAW92508 Q06418 AB209431 BAD92668 AK022124 AK131389 AK295496 BAG58416 BC029925 AAH29925 BC034960 BC049368 AAH49368 BC051756 AAH51756 D17517 BAA04467 D50479 BAA21781 DB483422 U02566 AAA17407 U05682 AAA19236 X72886 CAA51396 XM_011521992 XP_011520294 XM_011521993 XP_011520295 NM_006293 NP_006284
Function	Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppre
Subcellular Location	Cell membrane; Single-pass type I membrane protein.
Tissue Specificity	Abundant in the brain and lower levels in other tissues.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human TYRO3 protein fragment - ab64304 from Abcam Category Protein Prices $302.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Active human TYRO3 protein fragment - ab191642 from Abcam Category Protein Prices $618.00 Sizes 200 µg Source HEK 293 cells Species Human

Human TYRO3 peptide - ab95403 from Abcam Category Peptide

Human TYRO3 protein fragment - ab159767 from Abcam Category Protein Source Wheat germ Species Human

TYRO3 peptide - ab85099 from Abcam Category Peptide

TYRO3 Antibody Blocking Peptide - LS-E9186 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Dtk/TYRO3 Blocking Peptide - NBP1-28635PEP from Novus Biologicals Category Peptide Prices $69.00 Sizes 50 µg Species Human

Dtk/TYRO3 Partial Recombinant Protein - H00007301-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Dtk/TYRO3 Recombinant Protein - P4791 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

Dtk/TYRO3 Peptide - P2720 from Novus Biologicals Category Peptide Species Human

Dtk/TYRO3 Peptide - P2719 from Novus Biologicals Category Peptide Species Human

TYRO3-Antibody-C-term-Blocking-peptide - BP7679b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TYRO3-Antibody-N-term-Blocking-peptide - BP7679a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human Dtk Fc Chimera, CF - 859-DK-100 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

TYRO3 - H00007301-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

TYRO3 - H00007301-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

TYRO3 - P4791 from Acris Antibodies Category Protein Prices $1,380.00 Sizes 100 µg Species Human

TYRO3 - P5809 from Acris Antibodies Category Protein Prices $840.00 Sizes 5 µg Species Human

TYRO3 control peptide - AP10364CP-N from Acris Antibodies Category Peptide Prices $235.00 Sizes 100 µg

TYRO3 Recombinant Protein - 96-759 from ProSci Category Protein Prices $425.00 Sizes 200 µg Source HEK293 cells Species Human

TYRO3 fusion protein - Ag4825 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

TYRO3 fusion protein - ag5014 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human TYRO3 Protein Tyrosine Kinase, GST-tagged, Active - TYRO3-254H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus.

Recombinant Human TYRO3 Protein Tyrosine Kinase - TYRO3-484H from Creative Biomart Category Protein Source NSO Cells.

Recombinant Human TYRO3 Protein Tyrosine Kinase, GST-His - TYRO3-749H from Creative Biomart Category Protein Source Sf9 cells.

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