TYRO3

Gene Symbol	TYRO3
Entrez Gene	7301
Alt Symbol	BYK, Dtk, Etk-2, RSE, Rek, Sky, Tif
Species	Human
Gene Type	protein-coding
Description	TYRO3 protein tyrosine kinase
Other Description	tyrosine-protein kinase DTK|tyrosine-protein kinase RSE|tyrosine-protein kinase SKY|tyrosine-protein kinase TIF|tyrosine-protein kinase byk|tyrosine-protein kinase receptor TYRO3
Swissprots	Q86VR3 O14953 Q06418
Accessions	BAA05134 EAW92506 EAW92507 EAW92508 Q06418 AB209431 BAD92668 AK022124 AK131389 AK295496 BAG58416 BC029925 AAH29925 BC034960 BC049368 AAH49368 BC051756 AAH51756 D17517 BAA04467 D50479 BAA21781 DB483422 U02566 AAA17407 U05682 AAA19236 X72886 CAA51396 XM_011521992 XP_011520294 XM_011521993 XP_011520295 NM_006293 NP_006284
Function	Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppre
Subcellular Location	Cell membrane; Single-pass type I membrane protein.
Tissue Specificity	Abundant in the brain and lower levels in other tissues.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Tyro3 CRISPR/Cas9 KO Plasmid (h) - sc-401412 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Tyro3 HDR Plasmid (h) - sc-401412-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Tyro3 Double Nickase Plasmid (h) - sc-401412-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Tyro3 Double Nickase Plasmid (h2) - sc-401412-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Tyro3 CRISPR Activation Plasmid (h) - sc-401412-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Tyro3 CRISPR Activation Plasmid (h2) - sc-401412-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Tyro3 Lentiviral Activation Particles (h) - sc-401412-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Tyro3 Lentiviral Activation Particles (h2) - sc-401412-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Tyro3 siRNA (h) - sc-36438 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Tyro3 shRNA Plasmid (h) - sc-36438-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Tyro3 shRNA (h) Lentiviral Particles - sc-36438-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Dtk/TYRO3 RNAi - H00007301-R01V from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

Dtk/TYRO3 RNAi - H00007301-R04 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® siRNA - SIHK2403 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK2404 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK2405 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN2340 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2340 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR08042 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr08042

TYRO3 siRNA (Human) - CRH4994 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

TYRO3 - MBS8220182 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human TYRO3 (NM_006293.3) - SHH438456 from Creative biogene Category siRNA Species Reactivities Human

TYRO3 shRNA Plasmid (Human) - CHH4994 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

TYRO3 miRNA 3'UTR clone - MiUTR3H-03279 from Creative biogene Species Reactivities Human

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