| Gene Symbol |
TYRO3
|
| Entrez Gene |
7301
|
| Alt Symbol |
BYK, Dtk, Etk-2, RSE, Rek, Sky, Tif
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
TYRO3 protein tyrosine kinase
|
| Other Description |
tyrosine-protein kinase DTK|tyrosine-protein kinase RSE|tyrosine-protein kinase SKY|tyrosine-protein kinase TIF|tyrosine-protein kinase byk|tyrosine-protein kinase receptor TYRO3
|
| Swissprots |
Q86VR3 O14953 Q06418
|
| Accessions |
BAA05134 EAW92506 EAW92507 EAW92508 Q06418 AB209431 BAD92668 AK022124 AK131389 AK295496 BAG58416 BC029925 AAH29925 BC034960 BC049368 AAH49368 BC051756 AAH51756 D17517 BAA04467 D50479 BAA21781 DB483422 U02566 AAA17407 U05682 AAA19236 X72886 CAA51396 XM_011521992 XP_011520294 XM_011521993 XP_011520295 NM_006293 NP_006284
|
| Function |
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppre
|
| Subcellular Location |
Cell membrane; Single-pass type I membrane protein.
|
| Tissue Specificity |
Abundant in the brain and lower levels in other tissues.
|