MAP4K2

Gene Symbol	MAP4K2
Entrez Gene	5871
Alt Symbol	BL44, GCK, RAB8IP
Species	Human
Gene Type	protein-coding
Description	mitogen-activated protein kinase kinase kinase kinase 2
Other Description	B lymphocyte serine/threonine protein kinase|MAPK/ERK kinase kinase kinase 2|MEK kinase kinase 2|MEKKK 2|Rab8 interacting protein|germinal centre kinase (GC kinase)
Swissprots	Q86VU3 Q12851
Accessions	EAW74299 EAW74300 EAW74301 EAW74302 Q12851 AK298383 BAG60619 AK304495 BAG65303 AW574847 BC039839 BC047865 AAH47865 BM458161 BU844790 HY168726 U07349 AAA20968 XM_011545202 XP_011543504 XM_011545203 XP_011543505 XM_011545204 XP_011543506 NM_001307990 NP_001294919 NM_004579 NP_004570
Function	Serine/threonine-protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Acts as a MAPK kinase kinase kinase (MAP4K) and is an upstream activator of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway and to a lesser extend of the p38 MAPKs signaling pathway. Required for the efficient activation of JNKs by TRAF6-dependent stimuli, including pathogen-associated molecular patterns (PAMPs) such as polyinosine-polycytidine (poly(IC)), lipopolysaccharides (LPS), lipid A, peptidoglycan (PGN), or bacterial flagellin. To a lesser degree, IL-1 and engagement of CD40 also stimulate MAP4K2-mediated JNKs activation. The requirement for MAP4K2/GCK is most pronounced for LPS signaling, and extends to LPS stimulation of c-Jun phosphorylation and induction of IL-8. Enhances MAP3K1 oligomerization, which may relieve N-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. Mediates also
Subcellular Location	Cytoplasm {ECO:0000250}. Basolateral cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Tissue Specificity	Highly expressed in germinal center but not mantle zone B-cells. Also expressed in lung, brain and placenta and at lower levels in other tissues examined. {ECO:0000269|PubMed:7515885}.
Top Pathways	MAPK signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

MAP4K2 293T Cell Transient Overexpression Lysate(Denatured) - H00005871-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

MAP4K2 293 Cell Lysate - 408370 from ABBIOTEC Category Cell Lysate Prices $672.00 Sizes 100 µg

MAP4K2 Overexpression Lysate (Native) - NBP2-07852 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

GC kinase (h): 293T Lysate - sc-116216 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

MAP4K2 Over-expression Lysate Product - GWB-74340F from Genway Biotech Category Cell Lysate Prices $756.00 Sizes 100 µg Species Human

Human MAP4K2 / GC Kinase Insect Cell Lysate (WB positive control) - 11826-H20BL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human MAP4K2 Baculovirus-Insect Cells Transfected Lysate (positive control) (denatured) - orb175004 from Biorbyt Category Cell Lysate Prices $425.00 Sizes 300 μg Species Human

MAP4K2 Overexpression Lysate (Denatured) - H00005871-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Panoply™ Human MAP4K2 Knockdown Stable Cell Line - CSC-DC009182 from Creative biogene Category Cell Line Species Human

Search more