MAP4K2

Gene Symbol	MAP4K2
Entrez Gene	5871
Alt Symbol	BL44, GCK, RAB8IP
Species	Human
Gene Type	protein-coding
Description	mitogen-activated protein kinase kinase kinase kinase 2
Other Description	B lymphocyte serine/threonine protein kinase|MAPK/ERK kinase kinase kinase 2|MEK kinase kinase 2|MEKKK 2|Rab8 interacting protein|germinal centre kinase (GC kinase)
Swissprots	Q86VU3 Q12851
Accessions	EAW74299 EAW74300 EAW74301 EAW74302 Q12851 AK298383 BAG60619 AK304495 BAG65303 AW574847 BC039839 BC047865 AAH47865 BM458161 BU844790 HY168726 U07349 AAA20968 XM_011545202 XP_011543504 XM_011545203 XP_011543505 XM_011545204 XP_011543506 NM_001307990 NP_001294919 NM_004579 NP_004570
Function	Serine/threonine-protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Acts as a MAPK kinase kinase kinase (MAP4K) and is an upstream activator of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway and to a lesser extend of the p38 MAPKs signaling pathway. Required for the efficient activation of JNKs by TRAF6-dependent stimuli, including pathogen-associated molecular patterns (PAMPs) such as polyinosine-polycytidine (poly(IC)), lipopolysaccharides (LPS), lipid A, peptidoglycan (PGN), or bacterial flagellin. To a lesser degree, IL-1 and engagement of CD40 also stimulate MAP4K2-mediated JNKs activation. The requirement for MAP4K2/GCK is most pronounced for LPS signaling, and extends to LPS stimulation of c-Jun phosphorylation and induction of IL-8. Enhances MAP3K1 oligomerization, which may relieve N-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. Mediates also
Subcellular Location	Cytoplasm {ECO:0000250}. Basolateral cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Tissue Specificity	Highly expressed in germinal center but not mantle zone B-cells. Also expressed in lung, brain and placenta and at lower levels in other tissues examined. {ECO:0000269|PubMed:7515885}.
Top Pathways	MAPK signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Germinal Center Kinase full length protein - ab89753 from Abcam Category Protein Prices $302.00, $352.00, $1,845.00 Sizes 5 µg, 10 µg, 100 µg Source Baculovirus infected sf9 cells Species Human

Human Germinal Center Kinase full length protein - ab159296 from Abcam Category Protein Source Wheat germ Species Human

Recombinant Human MAP4K2 Protein - H00005871-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

MAP4K2 Peptide - P2170 from Novus Biologicals Category Peptide Species Human

MAP4K2-Antibody-Center-Blocking-peptide - BP12341c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Germinal-Center-Kinase-GCKMAP4K2-Antibody-Center-Blocking-peptide - BP7065b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human MAP4K2 His GST tag protein - orb84095 from Biorbyt Category Protein Prices $323.00, $646.00 Sizes 20 μg, 100 μg Source Insect Species Human

MAP4K2 Blocking Peptide - 33R-9374 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

MAP4K2 Blocking Peptide - 33R-3778 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

MAP4K2 - H00005871-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

MAP4K2 - H00005871-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

MAP4K2 - P5593 from Acris Antibodies Category Protein Prices $1,010.00 Sizes 5 µg Species Human

Recombinant Human MAP4K2, His & GST tagged - MAP4K2-1167H from Creative Biomart Category Protein Source Baculovirus-Insect Cells Species Human

Recombinant Human MAP4K2 - MAP4K2-28743TH from Creative Biomart Category Protein

Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2, His-tagged - MAP4K2-1263H from Creative Biomart Category Protein Source Insect cells Species Human

Recombinant Human MAP4K2, GST-tagged - MAP4K2-934H from Creative Biomart Category Protein Species Human

MAP4K2 / GCK - PN201667 from Elabscience Category Protein Prices $225.00, $475.00 Sizes 10 μg, 50 μg Source Baculovirus Species Human

Recombinant Human Mitogen-activated protein kinase kinase kinase kinase 2(MAP4K2 - CSB-YP013437HU CSB-EP013437HU CSB-BP013437HU CSB-MP013437HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

MAP4K2 - TP317608 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Species Human

Human MAP4K2 / GC Kinase Protein (His & GST Tag) - 11826-H20B-20 from Sino Biological Category Protein Source Baculovirus-Insect Cells Species Human

Recombinant Human GCK GST - CSI13426 from Cell Science Prices $615.00 Sizes 10 μg Species Human

Recombinant Human MAP4K2 / GC Kinase Protein (His & GST tag) - PKSH030347 from Elabscience Category Protein Source Baculoviru Species Human

MAP4K2 Recombinant Protein Antigen - NBP1-88584PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

GCK Protein, active, 10 µg - 14-743 from EMD Millipore Category Protein Prices $329.00 Sizes 10 µg Source Recombinant protein expressed in Sf21 cells

GCK Protein, active, 250 µg - 14-743M from EMD Millipore Category Protein Prices $2,544.00 Sizes 250 µg also available in 10 μg size . (cat#14-743) and in bulk (cat# 14-743-K) Source Recombinant protein expressed in Sf21 cells

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