| Gene Symbol |
MAP4K2
|
| Entrez Gene |
5871
|
| Alt Symbol |
BL44, GCK, RAB8IP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mitogen-activated protein kinase kinase kinase kinase 2
|
| Other Description |
B lymphocyte serine/threonine protein kinase|MAPK/ERK kinase kinase kinase 2|MEK kinase kinase 2|MEKKK 2|Rab8 interacting protein|germinal centre kinase (GC kinase)
|
| Swissprots |
Q86VU3 Q12851
|
| Accessions |
EAW74299 EAW74300 EAW74301 EAW74302 Q12851 AK298383 BAG60619 AK304495 BAG65303 AW574847 BC039839 BC047865 AAH47865 BM458161 BU844790 HY168726 U07349 AAA20968 XM_011545202 XP_011543504 XM_011545203 XP_011543505 XM_011545204 XP_011543506 NM_001307990 NP_001294919 NM_004579 NP_004570
|
| Function |
Serine/threonine-protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Acts as a MAPK kinase kinase kinase (MAP4K) and is an upstream activator of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway and to a lesser extend of the p38 MAPKs signaling pathway. Required for the efficient activation of JNKs by TRAF6-dependent stimuli, including pathogen-associated molecular patterns (PAMPs) such as polyinosine-polycytidine (poly(IC)), lipopolysaccharides (LPS), lipid A, peptidoglycan (PGN), or bacterial flagellin. To a lesser degree, IL-1 and engagement of CD40 also stimulate MAP4K2-mediated JNKs activation. The requirement for MAP4K2/GCK is most pronounced for LPS signaling, and extends to LPS stimulation of c-Jun phosphorylation and induction of IL-8. Enhances MAP3K1 oligomerization, which may relieve N-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. Mediates also
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Basolateral cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Highly expressed in germinal center but not mantle zone B-cells. Also expressed in lung, brain and placenta and at lower levels in other tissues examined. {ECO:0000269|PubMed:7515885}.
|
| Top Pathways |
MAPK signaling pathway
|