MAP4K2

Gene Symbol	MAP4K2
Entrez Gene	5871
Alt Symbol	BL44, GCK, RAB8IP
Species	Human
Gene Type	protein-coding
Description	mitogen-activated protein kinase kinase kinase kinase 2
Other Description	B lymphocyte serine/threonine protein kinase|MAPK/ERK kinase kinase kinase 2|MEK kinase kinase 2|MEKKK 2|Rab8 interacting protein|germinal centre kinase (GC kinase)
Swissprots	Q86VU3 Q12851
Accessions	EAW74299 EAW74300 EAW74301 EAW74302 Q12851 AK298383 BAG60619 AK304495 BAG65303 AW574847 BC039839 BC047865 AAH47865 BM458161 BU844790 HY168726 U07349 AAA20968 XM_011545202 XP_011543504 XM_011545203 XP_011543505 XM_011545204 XP_011543506 NM_001307990 NP_001294919 NM_004579 NP_004570
Function	Serine/threonine-protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Acts as a MAPK kinase kinase kinase (MAP4K) and is an upstream activator of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway and to a lesser extend of the p38 MAPKs signaling pathway. Required for the efficient activation of JNKs by TRAF6-dependent stimuli, including pathogen-associated molecular patterns (PAMPs) such as polyinosine-polycytidine (poly(IC)), lipopolysaccharides (LPS), lipid A, peptidoglycan (PGN), or bacterial flagellin. To a lesser degree, IL-1 and engagement of CD40 also stimulate MAP4K2-mediated JNKs activation. The requirement for MAP4K2/GCK is most pronounced for LPS signaling, and extends to LPS stimulation of c-Jun phosphorylation and induction of IL-8. Enhances MAP3K1 oligomerization, which may relieve N-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. Mediates also
Subcellular Location	Cytoplasm {ECO:0000250}. Basolateral cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Tissue Specificity	Highly expressed in germinal center but not mantle zone B-cells. Also expressed in lung, brain and placenta and at lower levels in other tissues examined. {ECO:0000269|PubMed:7515885}.
Top Pathways	MAPK signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

GCK Antibody - 3782 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Polyclonal

GC kinase (A-10) - sc-398967 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

GC kinase (N-19) - sc-6161 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-Germinal Center Kinase antibody - ab38289 from Abcam Prices $359.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Germinal Center Kinase antibody - ab170695 from Abcam Prices $370.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-Germinal Center Kinase antibody - ab167532 from Abcam Prices $370.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-Germinal Center Kinase antibody - ab82870 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-Germinal Center Kinase antibody [EPR14304] - ab184169 from Abcam Prices $357.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR14304

Anti-GCK / Germinal Center Kinase Antibody (aa431-459, APC) - LS-C223199 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-GCK / Germinal Center Kinase Antibody (aa320-349, PE) - LS-C223197 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-GCK / Germinal Center Kinase Antibody (aa431-459, AP) - LS-C223198 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-GCK / Germinal Center Kinase Antibody (aa431-459, FITC) - LS-C223201 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-GCK / Germinal Center Kinase Antibody (aa431-459, Biotin) - LS-C223200 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-GCK / Germinal Center Kinase Antibody (aa431-459, Azide-free, HRP) - LS-C223202 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-GCK / Germinal Center Kinase Antibody (aa431-459, PE) - LS-C223203 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-GCK / Germinal Center Kinase Antibody (aa36-85) - LS-C81267 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-GCK / Germinal Center Kinase Antibody (AP) - LS-C225550 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-GCK / Germinal Center Kinase Antibody (APC) - LS-C225551 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-GCK / Germinal Center Kinase Antibody (FITC) - LS-C225552 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-GCK / Germinal Center Kinase Antibody (PE) - LS-C225555 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-GCK / Germinal Center Kinase Antibody (Biotin) - LS-C225553 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-GCK / Germinal Center Kinase Antibody (aa216-265) - LS-C81268 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-GCK / Germinal Center Kinase Antibody (Azide-free, HRP) - LS-C225554 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-GCK / Germinal Center Kinase Antibody (aa320-349, APC) - LS-C226862 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-GCK / Germinal Center Kinase Antibody (aa432-459) - LS-C164460 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

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