| Gene Symbol |
CNOT6L
|
| Entrez Gene |
246175
|
| Alt Symbol |
CCR4b
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
CCR4-NOT transcription complex, subunit 6-like
|
| Other Description |
CCR4-NOT transcription complex subunit 6-like|carbon catabolite repressor protein 4 homolog B
|
| Swissprots |
Q96LI5 Q9UF92
|
| Accessions |
EAX05818 EAX05819 Q96LI5 AK027214 AK058188 BAB71707 AK124855 AK303417 BAG64470 AK304397 BAG65232 AL133112 CAB61415 BC152816 AAI52817 DA043791 DB454180 XM_011531806 XP_011530108 XM_011531807 XP_011530109 XM_011531808 XP_011530110 XM_011531809 XP_011530111 XM_011531810 XP_011530112 NM_001286790 NP_001273719 NM_144571 NP_653172
|
| Function |
Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in the deadenylation-dependent degradation of mRNAs through the 3'-UTR AU-rich element-mediated mechanism. Involved in deadenylation-dependent degradation of CDKN1B mRNA. Its mRNA deadenylase activity can be inhibited by TOB1. Mediates cell proliferation and cell survival and prevents cellular senescence. {ECO:0000269|PubMed:17452450, ECO:0000269|PubMed:21233283}.
|
| Subcellular Location |
Cytoplasm. Nucleus.
|
| Tissue Specificity |
Highly expressed in placenta, skeletal muscle, pancreas, testis and leukocytes. Weakly expressed in heart, spleen and thymus. {ECO:0000269|PubMed:17452450}.
|
| Top Pathways |
RNA degradation
|