CNOT6L

Gene Symbol CNOT6L
Entrez Gene 246175
Alt Symbol CCR4b
Species Human
Gene Type protein-coding
Description CCR4-NOT transcription complex, subunit 6-like
Other Description CCR4-NOT transcription complex subunit 6-like|carbon catabolite repressor protein 4 homolog B
Swissprots Q96LI5 Q9UF92
Accessions EAX05818 EAX05819 Q96LI5 AK027214 AK058188 BAB71707 AK124855 AK303417 BAG64470 AK304397 BAG65232 AL133112 CAB61415 BC152816 AAI52817 DA043791 DB454180 XM_011531806 XP_011530108 XM_011531807 XP_011530109 XM_011531808 XP_011530110 XM_011531809 XP_011530111 XM_011531810 XP_011530112 NM_001286790 NP_001273719 NM_144571 NP_653172
Function Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in the deadenylation-dependent degradation of mRNAs through the 3'-UTR AU-rich element-mediated mechanism. Involved in deadenylation-dependent degradation of CDKN1B mRNA. Its mRNA deadenylase activity can be inhibited by TOB1. Mediates cell proliferation and cell survival and prevents cellular senescence. {ECO:0000269|PubMed:17452450, ECO:0000269|PubMed:21233283}.
Subcellular Location Cytoplasm. Nucleus.
Tissue Specificity Highly expressed in placenta, skeletal muscle, pancreas, testis and leukocytes. Weakly expressed in heart, spleen and thymus. {ECO:0000269|PubMed:17452450}.
Top Pathways RNA degradation

CNOT6L (L-16) - sc-246305 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

CNOT6L (P-18) - sc-246304 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-CNO6L antibody - ab178730 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-CNO6L antibody (ab178730) at 1 µg/ml + HepG2 whole cell lysate at 10 µg

Anti-CNO6L antibody - ab103659 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-CNO6L antibody (ab103659) + Sk-Br-3 cell lysate at 35 µg

Anti-CNOT6L Antibody (aa422-452) - LS-C168886 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
CNO6L Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human skeletal muscle followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-CNOT6L Antibody (aa422-452, AP) - LS-C255143 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CNOT6L Antibody (aa422-452, APC) - LS-C255144 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CNOT6L Antibody (aa422-452, Biotin) - LS-C255145 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CNOT6L Antibody (aa422-452, FITC) - LS-C255146 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CNOT6L Antibody (aa422-452, Azide-free, HRP) - LS-C255147 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CNOT6L Antibody (aa422-452, PE) - LS-C255148 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CNOT6L Antibody (aa422-452) - LS-C320487 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CNOT6L Antibody (aa242-291) - LS-C186809 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Human HepG2. CNOT6L antibody dilution 1.0 ug/ml.

CNOT6L Antibody - NBP1-84186 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: CNOT6L Antibody [NBP1-84186] - Analysis in human cell line MOLT-4.

ANTI-CNO6L (C-TERM) antibody produced in rabbit - SAB1303263 from Sigma-Aldrich

Prices $326.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>CNO6L (C-term): <B>Cat. No. SAB1303263</B>: CNO6L in Human skeletal muscle tissue with CNO6L antibody (C-term) at 5 μg/mL.

Anti-CNOT6L antibody produced in rabbit - HPA042688 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-CNOT6L: <B>Cat. No. HPA042688</B>: Immunohistochemical staining of human skeletal muscle shows strong cytoplasmic positivity in myocytes.

CNOT6L Antibody - middle region (ARP66542_P050) - ARP66542_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

CNO6L Antibody - C-terminal region (OAAB02624) - OAAB02624 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

CNO6L-Antibody-C-term - AP5207a from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
CNO6L Antibody (C-term) (Cat. #AP5207a) immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CNO6L Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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