| Gene Symbol | CNOT6L |
|---|---|
| Entrez Gene | 246175 |
| Alt Symbol | CCR4b |
| Species | Human |
| Gene Type | protein-coding |
| Description | CCR4-NOT transcription complex, subunit 6-like |
| Other Description | CCR4-NOT transcription complex subunit 6-like|carbon catabolite repressor protein 4 homolog B |
| Swissprots | Q96LI5 Q9UF92 |
| Accessions | EAX05818 EAX05819 Q96LI5 AK027214 AK058188 BAB71707 AK124855 AK303417 BAG64470 AK304397 BAG65232 AL133112 CAB61415 BC152816 AAI52817 DA043791 DB454180 XM_011531806 XP_011530108 XM_011531807 XP_011530109 XM_011531808 XP_011530110 XM_011531809 XP_011530111 XM_011531810 XP_011530112 NM_001286790 NP_001273719 NM_144571 NP_653172 |
| Function | Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in the deadenylation-dependent degradation of mRNAs through the 3'-UTR AU-rich element-mediated mechanism. Involved in deadenylation-dependent degradation of CDKN1B mRNA. Its mRNA deadenylase activity can be inhibited by TOB1. Mediates cell proliferation and cell survival and prevents cellular senescence. {ECO:0000269|PubMed:17452450, ECO:0000269|PubMed:21233283}. |
| Subcellular Location | Cytoplasm. Nucleus. |
| Tissue Specificity | Highly expressed in placenta, skeletal muscle, pancreas, testis and leukocytes. Weakly expressed in heart, spleen and thymus. {ECO:0000269|PubMed:17452450}. |
| Top Pathways | RNA degradation |
CNOT6L CRISPR/Cas9 KO Plasmid (h) - sc-416617 from Santa Cruz Biotechnology
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CNOT6L HDR Plasmid (h) - sc-416617-HDR from Santa Cruz Biotechnology
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CNOT6L Double Nickase Plasmid (h) - sc-416617-NIC from Santa Cruz Biotechnology
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CNOT6L Double Nickase Plasmid (h2) - sc-416617-NIC-2 from Santa Cruz Biotechnology
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CNOT6L CRISPR Activation Plasmid (h) - sc-416617-ACT from Santa Cruz Biotechnology
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CNOT6L CRISPR Activation Plasmid (h2) - sc-416617-ACT-2 from Santa Cruz Biotechnology
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CNOT6L Lentiviral Activation Particles (h) - sc-416617-LAC from Santa Cruz Biotechnology
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CNOT6L Lentiviral Activation Particles (h2) - sc-416617-LAC-2 from Santa Cruz Biotechnology
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CNOT6L siRNA (h) - sc-105221 from Santa Cruz Biotechnology
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CNOT6L shRNA Plasmid (h) - sc-105221-SH from Santa Cruz Biotechnology
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CNOT6L shRNA (h) Lentiviral Particles - sc-105221-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU115471 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6324 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6324 from Sigma-Aldrich
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CNOT6L siRNA (Human) - CRJ6616 from Cohesion Biosciences
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CNOT6L RNAi - H00246175-R01 from Novus Biologicals
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CNOT6L - MBS8225137 from MyBioSource
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shRNA set against Human Cnot6l (NM_144571.2) - SHH266473 from Creative biogene
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shRNA set against Human CNOT6L(NM_144571.2) - SHG187831 from Creative biogene
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Human CNOT6L siRNA - orb277117 from Biorbyt
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CNOT6L shRNA Plasmid (Human) - CHJ6616 from Cohesion Biosciences
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CNOT6L miRNA 3'UTR clone - MiUTR1H-02280 from Creative biogene
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