CNOT6L

Gene Symbol CNOT6L
Entrez Gene 246175
Alt Symbol CCR4b
Species Human
Gene Type protein-coding
Description CCR4-NOT transcription complex, subunit 6-like
Other Description CCR4-NOT transcription complex subunit 6-like|carbon catabolite repressor protein 4 homolog B
Swissprots Q96LI5 Q9UF92
Accessions EAX05818 EAX05819 Q96LI5 AK027214 AK058188 BAB71707 AK124855 AK303417 BAG64470 AK304397 BAG65232 AL133112 CAB61415 BC152816 AAI52817 DA043791 DB454180 XM_011531806 XP_011530108 XM_011531807 XP_011530109 XM_011531808 XP_011530110 XM_011531809 XP_011530111 XM_011531810 XP_011530112 NM_001286790 NP_001273719 NM_144571 NP_653172
Function Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in the deadenylation-dependent degradation of mRNAs through the 3'-UTR AU-rich element-mediated mechanism. Involved in deadenylation-dependent degradation of CDKN1B mRNA. Its mRNA deadenylase activity can be inhibited by TOB1. Mediates cell proliferation and cell survival and prevents cellular senescence. {ECO:0000269|PubMed:17452450, ECO:0000269|PubMed:21233283}.
Subcellular Location Cytoplasm. Nucleus.
Tissue Specificity Highly expressed in placenta, skeletal muscle, pancreas, testis and leukocytes. Weakly expressed in heart, spleen and thymus. {ECO:0000269|PubMed:17452450}.
Top Pathways RNA degradation

CNOT6L Antibody Blocking Peptide - LS-E7769 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

CNOT6L Antibody Blocking Peptide - LS-E24155 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

CNO6L-Antibody-C-term-Blocking-peptide - BP5207a from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

Recombinant Human CCR4-NOT transcription complex subunit 6-like(CNOT6L) - CSB-YP846658HU CSB-EP846658HU CSB-BP846658HU CSB-MP846658HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

CNOT6L - TP319766 from Acris Antibodies

Category Protein
Prices $680.00
Sizes 20 µg
Source HEK293 cells
Species Human
CCR4-NOT transcription complex, subunit 6-like (CNOT6L)

CCR4-NOT transcription complex subunit 6-like (CNOT6L), Recombinant Protein - MBS1312008 from MyBioSource

Category Protein
Prices $1,350.00, $1,350.00, $1,570.00, $1,570.00, $2,240.00, $2,240.00, $2,705.00, $2,705.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human

CNOT6L Recombinant Protein Antigen - NBP1-84186PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

CNOT6L Peptide, Human - M34GP03383H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human
Search more