| Gene Symbol |
SRGAP1
|
| Entrez Gene |
57522
|
| Alt Symbol |
ARHGAP13
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SLIT-ROBO Rho GTPase activating protein 1
|
| Other Description |
SLIT-ROBO Rho GTPase-activating protein 1|rho GTPase-activating protein 13
|
| Swissprots |
Q9P2P2 Q9H8A3 Q7Z6B7
|
| Accessions |
EAW97122 EAW97123 Q7Z6B7 AB037725 BAA92542 AK023899 AK025819 AK123684 BC006127 BC029919 BC053903 AAH53903 XM_005269042 XP_005269099 XM_011538580 XP_011536882 XM_011538581 XP_011536883 XM_011538582 XP_011536884 XM_011538583 XP_011536885 NM_020762 NP_065813
|
| Function |
GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42. {ECO:0000269|PubMed:11672528}.
|
| Tissue Specificity |
Expressed in brain, lung, kidney, and testis. {ECO:0000269|PubMed:11672528}.
|
| Top Pathways |
Axon guidance
|