SRGAP1

Gene Symbol SRGAP1
Entrez Gene 57522
Alt Symbol ARHGAP13
Species Human
Gene Type protein-coding
Description SLIT-ROBO Rho GTPase activating protein 1
Other Description SLIT-ROBO Rho GTPase-activating protein 1|rho GTPase-activating protein 13
Swissprots Q9P2P2 Q9H8A3 Q7Z6B7
Accessions EAW97122 EAW97123 Q7Z6B7 AB037725 BAA92542 AK023899 AK025819 AK123684 BC006127 BC029919 BC053903 AAH53903 XM_005269042 XP_005269099 XM_011538580 XP_011536882 XM_011538581 XP_011536883 XM_011538582 XP_011536884 XM_011538583 XP_011536885 NM_020762 NP_065813
Function GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42. {ECO:0000269|PubMed:11672528}.
Tissue Specificity Expressed in brain, lung, kidney, and testis. {ECO:0000269|PubMed:11672528}.
Top Pathways Axon guidance

SRGAP1 (D-11) - sc-390349 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SRGAP1 (D-11): sc-390349. Western blot analysis of SRGAP1 expression in HeLa (A) and WI 38 (B) whole cell lysates.

SRGAP1 (G-10) - sc-390352 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SRGAP1 (G-10): sc-390352. Western blot analysis of SRGAP1 expression in IMR-32 (A) and WI 38 (B) whole cell lysates.

SRGAP1 (H-80) - sc-292040 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
SRGAP1 (H-80): sc-292040. Western blot analysis of SRGAP1 expression in IMR-32 whole cell lysate.

SRGAP1 (S-14) - sc-169424 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

SRGAP1 (P-15) - sc-169423 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

SRGAP1 (SQ-6) - sc-81939 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
SRGAP1 (SQ-6): sc-81939. Western blot analysis of SRGAP1 expression in IMR-32 whole cell lysate.

Anti-SRGAP1 antibody - ab57504 from Abcam

Prices $380.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
ICC/IF image of ab57504 stained HeLa cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab57504 at 10µg/ml overnight at +4°C. The secondary antibody (green) was DyLight® 488 goat anti- mouse (ab96879) IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-SRGAP1 antibody - ab76926 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SRGAP1 antibody (ab76926) at 1/2000 dilutionLane 1 : COS7 Whole cell lysateLane 2 : HEK293H Whole cell lysateLane 3 : HEK293H Whole cell lysate overexpressing human srGAP1Lane 4 : HEK293H whole cell lysate overexpressing human srGAP2Lane 5 : HEK293H whole cell lysate overexpressing human srGAP3Lane 6 : HeLa whole cell lysate overexpressing mouse srGAP2Lane 7 : Mouse E14 hindbrain lysateLysates/proteins at 30 µg per lane.SecondaryGoat polyclonal to Rabbit IgG Conjugated to HRP at 1/20000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-SRGAP1 antibody - ab169470 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-SRGAP1 antibody (ab169470) at 1 µg/mlLane 1 : SRGAP1 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysate Lysates/proteins at 15 µl per lane.developed using the ECL technique

Anti-SRGAP1 antibody - ab75281 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Detection of SRGAP1 by Western Blot of Immunprecipitate. anti-SRGAP1 at 1µg/ml staining SRGAP1 in HeLa whole cell lysate immunoprecipitated using ab75281 at 3µg/mg lysate (1 mg/IP; 20% of IP loaded/lane). Detection: Chemiluminescence with exposure time of 1 second.

Anti-SRGAP1 antibody [EPR8760(2)] - ab171938 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR8760(2)
Flow cytometric analysis of permeabilized 293T cells labeling SRGAP1 with ab171938 at 1/100 (red) or a rabbit IgG (negative) (green).

Anti-SRGAP1 Antibody (aa825-875) - LS-C75986 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SRGAP1 Antibody (aa979-1029) - LS-C75985 from LifeSpan Bioscience

Prices $545.00
Sizes 20 µg
Host Rabbit
Clonality Polyclonal

Anti-SRGAP1 Antibody (aa469-497, AP) - LS-C224142 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SRGAP1 Antibody (aa469-497, APC) - LS-C224144 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SRGAP1 Antibody (aa469-497, Biotin) - LS-C224145 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SRGAP1 Antibody (aa469-497, PE) - LS-C227083 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SRGAP1 Antibody (aa469-497, FITC) - LS-C227081 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SRGAP1 Antibody (aa469-497, Azide-free, HRP) - LS-C227082 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SRGAP1 Antibody (aa979-1029) - LS-C288099 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SRGAP1 Antibody (aa825-875) - LS-C288095 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SRGAP1 Antibody (aa952-1051, Azide-free) - LS-C328758 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-SRGAP1 Antibody (aa468-497) - LS-C325376 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SRGAP1 Antibody (aa673-720) - LS-C135447 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SRGAP1 antibody LS-C135447 Western blot of Mouse Brain lysate. Antibody concentration 1 ug/ml.

Anti-SRGAP1 Antibody (aa469-497) - LS-C157091 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
SRGAP1 Antibody western blot of mouse stomach tissue lysates (35 ug/lane). The SRGAP1 antibody detected the SRGAP1 protein (arrow).
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