| Gene Symbol | VASP |
|---|---|
| Entrez Gene | 7408 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | vasodilator-stimulated phosphoprotein |
| Other Description | - |
| Swissprots | Q93035 P50552 B2RBT9 Q6PIZ1 |
| Accessions | CAA67109 CAA67147 EAW57362 EAW57363 EAW57364 EAW57365 P50552 AK314812 BAG37336 AL556269 BC026019 AAH26019 BC038224 AAH38224 BG751094 BG825983 Z46389 CAA86523 XM_005259199 XP_005259256 XM_005259200 XP_005259257 NM_003370 NP_003361 NM_001008736 |
| Function | Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin- bound actin monomers onto the barbed end of growing actin filaments. Plays a role in actin-based mobility of Listeria monocytogenes in host cells. Regulates actin dynamics in platelets and plays an important role in regulating platelet aggregation. {ECO:0000269|PubMed:10087267, ECO:0000269|PubMed:10438535, ECO:0000269|PubMed:15939738, ECO:0000269|PubMed:17082196, ECO:0000269|PubMed:18559661}. |
| Subcellular Location | Cytoplasm. Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Cell junction, tight junction {ECO:0000250}. Cell projection, lamellipodium membrane. Cell projection, filopodium membrane. Note=Targeted to stress fibers and focal adhesions through interaction with a number of proteins including MRL family members. Localizes to the plasma membrane in protruding lamellipodia and filopodial tips. Stimulation by thrombin or PMA, also translocates VASP to focal adhesions. Localized along the sides of actin filaments throughout the peripheral cytoplasm under basal conditions. In pre-apoptotic cells, colocalizes with MEFV in large specks (pyroptosomes). |
| Tissue Specificity | Highly expressed in platelets. {ECO:0000269|PubMed:7828592}. |
| Top Pathways | Focal adhesion, Leukocyte transendothelial migration, Fc gamma R-mediated phagocytosis, cGMP-PKG signaling pathway, Rap1 signaling pathway |