VASP

Gene Symbol	VASP
Entrez Gene	7408
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	vasodilator-stimulated phosphoprotein
Other Description	-
Swissprots	Q93035 P50552 B2RBT9 Q6PIZ1
Accessions	CAA67109 CAA67147 EAW57362 EAW57363 EAW57364 EAW57365 P50552 AK314812 BAG37336 AL556269 BC026019 AAH26019 BC038224 AAH38224 BG751094 BG825983 Z46389 CAA86523 XM_005259199 XP_005259256 XM_005259200 XP_005259257 NM_003370 NP_003361 NM_001008736
Function	Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin- bound actin monomers onto the barbed end of growing actin filaments. Plays a role in actin-based mobility of Listeria monocytogenes in host cells. Regulates actin dynamics in platelets and plays an important role in regulating platelet aggregation. {ECO:0000269|PubMed:10087267, ECO:0000269|PubMed:10438535, ECO:0000269|PubMed:15939738, ECO:0000269|PubMed:17082196, ECO:0000269|PubMed:18559661}.
Subcellular Location	Cytoplasm. Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Cell junction, tight junction {ECO:0000250}. Cell projection, lamellipodium membrane. Cell projection, filopodium membrane. Note=Targeted to stress fibers and focal adhesions through interaction with a number of proteins including MRL family members. Localizes to the plasma membrane in protruding lamellipodia and filopodial tips. Stimulation by thrombin or PMA, also translocates VASP to focal adhesions. Localized along the sides of actin filaments throughout the peripheral cytoplasm under basal conditions. In pre-apoptotic cells, colocalizes with MEFV in large specks (pyroptosomes).
Tissue Specificity	Highly expressed in platelets. {ECO:0000269|PubMed:7828592}.
Top Pathways	Focal adhesion, Leukocyte transendothelial migration, Fc gamma R-mediated phagocytosis, cGMP-PKG signaling pathway, Rap1 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® VASP siRNA I - 7637 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

SignalSilence ® VASP siRNA II - 7658 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

VASP CRISPR/Cas9 KO Plasmid (h) - sc-401104 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

VASP HDR Plasmid (h) - sc-401104-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

VASP Double Nickase Plasmid (h) - sc-401104-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

VASP Double Nickase Plasmid (h2) - sc-401104-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

VASP CRISPR Activation Plasmid (h) - sc-401104-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

VASP CRISPR Activation Plasmid (h2) - sc-401104-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

VASP Lentiviral Activation Particles (h) - sc-401104-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

VASP Lentiviral Activation Particles (h2) - sc-401104-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

VASP siRNA (h) - sc-29516 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

VASP shRNA Plasmid (h) - sc-29516-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

VASP shRNA (h) Lentiviral Particles - sc-29516-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU048421 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN22645 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22645 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

VASP siRNA (Human) - CRH5067 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

VASP - MBS827472 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human VASP (NM_003370.3) - SHH442320 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human VASP(NM_003370.3) - SHL121810 from Creative biogene Category siRNA Species Reactivities Human

Human VASP siRNA - orb265569 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

VASP shRNA Plasmid (Human) - CHH5067 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

VASP miRNA 3'UTR clone - MiUTR1H-11098 from Creative biogene Species Reactivities Human

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