VASP

Gene Symbol	VASP
Entrez Gene	7408
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	vasodilator-stimulated phosphoprotein
Other Description	-
Swissprots	Q93035 P50552 B2RBT9 Q6PIZ1
Accessions	CAA67109 CAA67147 EAW57362 EAW57363 EAW57364 EAW57365 P50552 AK314812 BAG37336 AL556269 BC026019 AAH26019 BC038224 AAH38224 BG751094 BG825983 Z46389 CAA86523 XM_005259199 XP_005259256 XM_005259200 XP_005259257 NM_003370 NP_003361 NM_001008736
Function	Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin- bound actin monomers onto the barbed end of growing actin filaments. Plays a role in actin-based mobility of Listeria monocytogenes in host cells. Regulates actin dynamics in platelets and plays an important role in regulating platelet aggregation. {ECO:0000269|PubMed:10087267, ECO:0000269|PubMed:10438535, ECO:0000269|PubMed:15939738, ECO:0000269|PubMed:17082196, ECO:0000269|PubMed:18559661}.
Subcellular Location	Cytoplasm. Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Cell junction, tight junction {ECO:0000250}. Cell projection, lamellipodium membrane. Cell projection, filopodium membrane. Note=Targeted to stress fibers and focal adhesions through interaction with a number of proteins including MRL family members. Localizes to the plasma membrane in protruding lamellipodia and filopodial tips. Stimulation by thrombin or PMA, also translocates VASP to focal adhesions. Localized along the sides of actin filaments throughout the peripheral cytoplasm under basal conditions. In pre-apoptotic cells, colocalizes with MEFV in large specks (pyroptosomes).
Tissue Specificity	Highly expressed in platelets. {ECO:0000269|PubMed:7828592}.
Top Pathways	Focal adhesion, Leukocyte transendothelial migration, Fc gamma R-mediated phagocytosis, cGMP-PKG signaling pathway, Rap1 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human VASP peptide - ab32244 from Abcam Category Peptide

Human VASP protein fragment - ab105601 from Abcam Category Protein Source E. coli Species Human

Human VASP protein fragment - ab125773 from Abcam Category Protein Source E. coli Species Human

VASP Antibody Blocking Peptide - LS-E2875 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

VASP Antibody Blocking Peptide - LS-E22382 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

VASP Antibody Blocking Peptide - LS-E22383 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

VASP Recombinant Protein - H00007408-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 25 ug 10 ug Species Human

Recombinant Human VASP Protein - NBP1-51073 from Novus Biologicals Category Protein Prices $349.00, $969.00 Sizes 50 µg, 250 µg Source E. coli Species Human

VASP-Antibody-C-term-Blocking-peptide - BP13999b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human VASP protein - orb169537 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Species Human

VASP (phospho-S157) Peptide - orb224238 from Biorbyt Category Peptide Prices $357.00, $723.00 Sizes 1 mg, 5 mg Species Human

VASP Blocking Peptide - 33R-10020 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

VASP Blocking Peptide - 33R-8488 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

VASP Blocking Peptide - 33R-10903 from Fitzgerald Category Peptide Prices $115.00 Sizes 50 µg

VASP protein (His tag) - 80R-1761 from Fitzgerald Category Protein Prices $340.00 Sizes 50 µg Source E.coli

VASP Blocking Peptide - abx063408 from Abbexa Category Peptide Species Human, Monkey

VASP Blocking Peptide - abx063409 from Abbexa Category Peptide Species Human, Rat, Bovine, Dog

VASP (1-343, His-tag) - AR09943PU-L from Acris Antibodies Category Protein Prices $1,020.00 Sizes 250 µg Source E. coli Species Human

VASP (1-343, His-tag) - AR09943PU-N from Acris Antibodies Category Protein Prices $420.00 Sizes 50 µg Source E. coli Species Human

VASP Control Peptide - AM00155CP-N from Acris Antibodies Category Peptide Prices $280.00 Sizes 100 µg

VASP control peptide - AM00156CP-N from Acris Antibodies Category Peptide Prices $280.00 Sizes 100 µg

Vasodilator-Stimulated Phosphoprotein, Human Recombinant - 228-12945-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Species Human

Recombinant Vasodilator-Stimulated Phosphoprotein Human - 228-12945-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Escherichia Coli. Species Human

Recombinant Vasodilator-Stimulated Phosphoprotein Human - 228-12945-3 from RayBiotech Category Protein Source Escherichia Coli. Species Human

VASP, 1-343aa, Human, His tag, E.coli - 01-P1003 from ARP American Research Products Category Protein Prices $179.00, $449.00, $1,089.00 Sizes 10 µg, 50 µg, 250 µg Species Human

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