ARHGEF1

Gene Symbol ARHGEF1
Entrez Gene 9138
Alt Symbol GEF1, LBCL2, LSC, P115-RHOGEF, SUB1.5
Species Human
Gene Type protein-coding
Description Rho guanine nucleotide exchange factor (GEF) 1
Other Description 115 kDa guanine nucleotide exchange factor|115-kD protein|Lsc homolog|p115RhoGEF|rho guanine nucleotide exchange factor 1
Swissprots Q96F17 Q6NX52 Q8N4J4 Q9BSB1 O00513 Q92888 Q96BF4
Accessions EAW57077 EAW57078 EAW57079 EAW57080 EAW57081 EAW57082 EAW57083 EAW57084 Q92888 AK026781 AL832294 BC005155 AAH05155 BC011726 AAH11726 BC015652 BC034013 AAH34013 BC035127 AAH35127 BC064996 BC067262 AAH67262 BM147791 BQ944132 BT007421 AAP36089 DQ893592 ABM84518 DQ895004 ABM85930 EU832644 ACE87735 EU832721 ACE87053 U64105 AAB17896 XM_005259386 XP_005259443 XM_005259387 XP_005259444 XM_005259388 XP_005259445 XM_005259389 XP_005259446 XM_005259390 XP_005259447 XM_006723463 XP_006723526 XM_011527468 XP_011525770 NM_004706 NP_004697 NM_198977 NP_945328 NM_199002 NP_945353
Function Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2- induced RhoA activation. {ECO:0000269|PubMed:20098430, ECO:0000269|PubMed:8810315, ECO:0000269|PubMed:9641915, ECO:0000269|PubMed:9641916}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:10747909}. Membrane {ECO:0000269|PubMed:10747909}. Note=Translocated to the membrane by activated GNA13 or LPA stimulation.
Tissue Specificity Ubiquitously expressed. {ECO:0000269|PubMed:8810315, ECO:0000269|PubMed:9135076}.
Top Pathways Vascular smooth muscle contraction, Proteoglycans in cancer, Regulation of actin cytoskeleton

p115 RhoGEF (D25D2) XP ® Rabbit mAb - 3669 from Cell Signaling Technology

Prices $277.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D25D2
Western blot analysis of extracts from various cell types using p115 RhoGEF (D25D2) XP ® Rabbit mAb.

RhoGEF p115/Lsc (C-19) - sc-8492 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
RhoGEF p115/Lsc (C-19): sc-8492. Western blot analysis of RhoGEF p115/Lsc expression in HeLa whole cell lysate.

RhoGEF p115/Lsc (D-11) - sc-166341 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
RhoGEF p115/Lsc (D-11): sc-166341. Western blot analysis of RhoGEF p115 expression in non-transfected: sc-117752 (A) and human RhoGEF p115 transfected: sc-113634 (B) 293T whole cell lysates.

RhoGEF p115/Lsc (E-16) - sc-32052 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
RhoGEF p115/Lsc (E-16): sc-32052. Western blot analysis of RhoGEF p115 expression in non-transfected: sc-117752 (A) and human RhoGEF p115 transfected: sc-113634 (B) 293T whole cell lysates.

RhoGEF p115/Lsc (E-4) - sc-166301 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
RhoGEF p115/Lsc (E-4): sc-166301. Western blot analysis of RhoGEF p115 expression in non-transfected: sc-117752 (A) and human RhoGEF p115 transfected: sc-113634 (B) 293T whole cell lysates.

RhoGEF p115/Lsc (R-15) - sc-32053 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
RhoGEF p115/Lsc (R-15): sc-32053. Western blot analysis of RhoGEF p115 expression in non-transfected: sc-117752 (A) and human RhoGEF p115 transfected: sc-175428 (B) 293T whole cell lysates.

RhoGEF p115/Lsc (H-165) - sc-20804 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
RhoGEF p115/Lsc (H-165): sc-20804. Western blot analysis of RhoGEF p115/Lsc expression in HeLa whole cell lysate.

RhoGEF p115/Lsc (B-7) - sc-373720 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
RhoGEF p115/Lsc (B-7): sc-373720. Western blot analysis of RhoGEF p115/Lsc expression in K-562 whole cell lysate.

RhoGEF p115 (YN-12) - sc-81901 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
RhoGEF p115 (YN-12): sc-81901. Western blot analysis of RhoGEF p115 expression in non-transfected: sc-117752 (A) and human RhoGEF p115 transfected: sc-113634 (B) 293T whole cell lysates.

Anti-ARHGEF1 antibody - ab199172 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue labeling ARHGEF1 with ab199172 at 1/50 dilution.

Anti-ARHGEF1 antibody - ab123582 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-ARHGEF1 antibody (ab123582) at 1/100 dilution + CEM cell line lysate at 35 µg

Anti-ARHGEF1 antibody - ab136062 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-ARHGEF1 antibody (ab136062) at 1/500 dilution + HepG2 cell lysate at 30 µg

Anti-ARHGEF1 antibody - ab56462 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab56462 ARHGEF1 antibody at 1ug/ml.

Anti-ARHGEF1 antibody - ab56464 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-ARHGEF1 Antibody (aa164-192, AP) - LS-C251657 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ARHGEF1 Antibody (aa164-192, APC) - LS-C251660 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ARHGEF1 Antibody (aa230-279) - LS-C151517 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ARHGEF1 antibody Western Blot of Jurkat.

Anti-ARHGEF1 Antibody (aa147-196) - LS-C200143 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of the lysates from HepG2 cells using ARHGEF1 antibody.

Anti-ARHGEF1 Antibody (aa164-192, Biotin) - LS-C251661 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ARHGEF1 Antibody (aa164-192, PE) - LS-C251664 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ARHGEF1 Antibody (aa164-192, FITC) - LS-C251662 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ARHGEF1 Antibody (aa275-325) - LS-C289421 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ARHGEF1 Antibody (aa164-192, Azide-free, HRP) - LS-C251663 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ARHGEF1 Antibody (aa775-825) - LS-C289422 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ARHGEF1 Antibody - LS-C309501 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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