ARHGEF1

Gene Symbol	ARHGEF1
Entrez Gene	9138
Alt Symbol	GEF1, LBCL2, LSC, P115-RHOGEF, SUB1.5
Species	Human
Gene Type	protein-coding
Description	Rho guanine nucleotide exchange factor (GEF) 1
Other Description	115 kDa guanine nucleotide exchange factor|115-kD protein|Lsc homolog|p115RhoGEF|rho guanine nucleotide exchange factor 1
Swissprots	Q96F17 Q6NX52 Q8N4J4 Q9BSB1 O00513 Q92888 Q96BF4
Accessions	EAW57077 EAW57078 EAW57079 EAW57080 EAW57081 EAW57082 EAW57083 EAW57084 Q92888 AK026781 AL832294 BC005155 AAH05155 BC011726 AAH11726 BC015652 BC034013 AAH34013 BC035127 AAH35127 BC064996 BC067262 AAH67262 BM147791 BQ944132 BT007421 AAP36089 DQ893592 ABM84518 DQ895004 ABM85930 EU832644 ACE87735 EU832721 ACE87053 U64105 AAB17896 XM_005259386 XP_005259443 XM_005259387 XP_005259444 XM_005259388 XP_005259445 XM_005259389 XP_005259446 XM_005259390 XP_005259447 XM_006723463 XP_006723526 XM_011527468 XP_011525770 NM_004706 NP_004697 NM_198977 NP_945328 NM_199002 NP_945353
Function	Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2- induced RhoA activation. {ECO:0000269|PubMed:20098430, ECO:0000269|PubMed:8810315, ECO:0000269|PubMed:9641915, ECO:0000269|PubMed:9641916}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:10747909}. Membrane {ECO:0000269|PubMed:10747909}. Note=Translocated to the membrane by activated GNA13 or LPA stimulation.
Tissue Specificity	Ubiquitously expressed. {ECO:0000269|PubMed:8810315, ECO:0000269|PubMed:9135076}.
Top Pathways	Vascular smooth muscle contraction, Proteoglycans in cancer, Regulation of actin cytoskeleton

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ARHGEF1 overexpression lysate - LY404700 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

ARHGEF1 overexpression lysate - LY404714 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

RhoGEF p115 (h): 293T Lysate - sc-113634 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

RhoGEF p115 (h3): 293T Lysate - sc-175428 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

RhoGEF p115 (h4): 293T Lysate - sc-175431 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

ARHGEF1 Overexpression Lysate (Native) - NBP2-04661 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

Panoply™ Human ARHGEF1 Knockdown Stable Cell Line - CSC-DC000878 from Creative biogene Category Cell Line Species Human

Human ARHGEF1 Knockout Cell Line-HEK293T - CSC-RT1231 from Creative biogene Category Cell Line Species Human

ARHGEF1 KO Cell Lysate-HEK293T - CLKO-1084 from Creative biogene Category Cell Lysate

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