| Gene Symbol | ARHGEF1 |
|---|---|
| Entrez Gene | 9138 |
| Alt Symbol | GEF1, LBCL2, LSC, P115-RHOGEF, SUB1.5 |
| Species | Human |
| Gene Type | protein-coding |
| Description | Rho guanine nucleotide exchange factor (GEF) 1 |
| Other Description | 115 kDa guanine nucleotide exchange factor|115-kD protein|Lsc homolog|p115RhoGEF|rho guanine nucleotide exchange factor 1 |
| Swissprots | Q96F17 Q6NX52 Q8N4J4 Q9BSB1 O00513 Q92888 Q96BF4 |
| Accessions | EAW57077 EAW57078 EAW57079 EAW57080 EAW57081 EAW57082 EAW57083 EAW57084 Q92888 AK026781 AL832294 BC005155 AAH05155 BC011726 AAH11726 BC015652 BC034013 AAH34013 BC035127 AAH35127 BC064996 BC067262 AAH67262 BM147791 BQ944132 BT007421 AAP36089 DQ893592 ABM84518 DQ895004 ABM85930 EU832644 ACE87735 EU832721 ACE87053 U64105 AAB17896 XM_005259386 XP_005259443 XM_005259387 XP_005259444 XM_005259388 XP_005259445 XM_005259389 XP_005259446 XM_005259390 XP_005259447 XM_006723463 XP_006723526 XM_011527468 XP_011525770 NM_004706 NP_004697 NM_198977 NP_945328 NM_199002 NP_945353 |
| Function | Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2- induced RhoA activation. {ECO:0000269|PubMed:20098430, ECO:0000269|PubMed:8810315, ECO:0000269|PubMed:9641915, ECO:0000269|PubMed:9641916}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:10747909}. Membrane {ECO:0000269|PubMed:10747909}. Note=Translocated to the membrane by activated GNA13 or LPA stimulation. |
| Tissue Specificity | Ubiquitously expressed. {ECO:0000269|PubMed:8810315, ECO:0000269|PubMed:9135076}. |
| Top Pathways | Vascular smooth muscle contraction, Proteoglycans in cancer, Regulation of actin cytoskeleton |
ARHGEF1 cDNA (ANA11176) - ANA11176 from Aviva Systems Biology
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ARHGEF1 cDNA (ANA11227) - ANA11227 from Aviva Systems Biology
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ARHGEF1 cDNA (ANA11228) - ANA11228 from Aviva Systems Biology
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ARHGEF1 - MBS1269840 from MyBioSource
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ARHGEF1 - MBS1271035 from MyBioSource
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Human ARHGEF1 cDNA clone(NM_198977.1) - CDFG013010 from Creative Biomart
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Human ARHGEF1 cDNA clone(NM_199002.1) - CDFG013026 from Creative Biomart
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Human ARHGEF1 cDNA clone(NM_004706.3) - CDFH001104 from Creative Biomart |
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Human ARHGEF1 cDNA clone(NM_004706.3) - CDFH001105 from Creative Biomart
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Human ARHGEF1 ORF Clone(NM_004706.3) - CDCR288666 from Creative Biomart
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Human ARHGEF1 ORF Clone(NM_004706.3) - CDCR288667 from Creative Biomart
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Human ARHGEF1 ORF Clone(NM_198977.1) - CDCR326437 from Creative Biomart
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Human ARHGEF1 ORF Clone(NM_198977.1) - CDCR326438 from Creative Biomart
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Human ARHGEF1 ORF Clone(NM_199002.1) - CDCR326468 from Creative Biomart
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Human ARHGEF1 ORF Clone(NM_199002.1) - CDCR326469 from Creative Biomart
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Human ARHGEF1 ORF Clone(NM_199002.1) - CDCR326470 from Creative Biomart
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Human ARHGEF1 ORF Clone(NM_004706.3) - CDCL154313 from Creative Biomart
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Human ARHGEF1 ORF Clone(NM_004706.3) - CDCL154314 from Creative Biomart
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Human ARHGEF1 ORF Clone(NM_004706.3) - CDCL154315 from Creative Biomart
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Human ARHGEF1 ORF Clone(NM_004706.3) - CDCL154316 from Creative Biomart
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Human ARHGEF1 ORF Clone(NM_198977.1) - CDCR326437 from Creative biogene
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Human ARHGEF1 ORF clone (NM_199002.1) - CDCR029758 from Creative biogene
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Human ARHGEF1 ORF clone (NM_004706.3) - CDCR029774 from Creative biogene
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Human ARHGEF1 ORF Clone (BC034013) - CDCS411919 from Creative biogene
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Human ARHGEF1 ORF Clone (BC011726) - CDCS411920 from Creative biogene
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