ARHGEF1

Gene Symbol	ARHGEF1
Entrez Gene	9138
Alt Symbol	GEF1, LBCL2, LSC, P115-RHOGEF, SUB1.5
Species	Human
Gene Type	protein-coding
Description	Rho guanine nucleotide exchange factor (GEF) 1
Other Description	115 kDa guanine nucleotide exchange factor|115-kD protein|Lsc homolog|p115RhoGEF|rho guanine nucleotide exchange factor 1
Swissprots	Q96F17 Q6NX52 Q8N4J4 Q9BSB1 O00513 Q92888 Q96BF4
Accessions	EAW57077 EAW57078 EAW57079 EAW57080 EAW57081 EAW57082 EAW57083 EAW57084 Q92888 AK026781 AL832294 BC005155 AAH05155 BC011726 AAH11726 BC015652 BC034013 AAH34013 BC035127 AAH35127 BC064996 BC067262 AAH67262 BM147791 BQ944132 BT007421 AAP36089 DQ893592 ABM84518 DQ895004 ABM85930 EU832644 ACE87735 EU832721 ACE87053 U64105 AAB17896 XM_005259386 XP_005259443 XM_005259387 XP_005259444 XM_005259388 XP_005259445 XM_005259389 XP_005259446 XM_005259390 XP_005259447 XM_006723463 XP_006723526 XM_011527468 XP_011525770 NM_004706 NP_004697 NM_198977 NP_945328 NM_199002 NP_945353
Function	Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2- induced RhoA activation. {ECO:0000269|PubMed:20098430, ECO:0000269|PubMed:8810315, ECO:0000269|PubMed:9641915, ECO:0000269|PubMed:9641916}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:10747909}. Membrane {ECO:0000269|PubMed:10747909}. Note=Translocated to the membrane by activated GNA13 or LPA stimulation.
Tissue Specificity	Ubiquitously expressed. {ECO:0000269|PubMed:8810315, ECO:0000269|PubMed:9135076}.
Top Pathways	Vascular smooth muscle contraction, Proteoglycans in cancer, Regulation of actin cytoskeleton

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ARHGEF1 full length protein - ab132603 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Human ARHGEF1 peptide - ab104428 from Abcam Category Peptide Prices $176.00 Sizes 100 µg

ARHGEF1 Antibody Blocking Peptide - LS-E3668 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ARHGEF1 Antibody Blocking Peptide - LS-E23093 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ARHGEF1 Recombinant Protein - H00009138-P02 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human ARHGEF1 Protein - H00009138-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

ARHGEF1-Antibody-N-term-Blocking-Peptide - BP14869a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ARHGEF1 Protein Lysate (APL11227) - APL11227 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

ARHGEF1 Protein Lysate (APL11228) - APL11228 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

ARHGEF1 Blocking Peptide - abx063552 from Abbexa Category Peptide Species Human, Mouse, Rat

ARHGEF1 - H00009138-P02 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

ARHGEF1 - H00009138-P02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

ARHGEF1 - H00009138-P02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

ARHGEF1 - H00009138-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

ARHGEF1 - H00009138-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

ARHGEF1 fusion protein - ag1905 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human ARHGEF1, His-tagged - ARHGEF1-27183TH from Creative Biomart Category Protein Source E. coli

ARHGEF1 Blocking Peptide - CBP2358 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

ARHGEF1 Peptide - BS5901P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human Rho guanine nucleotide exchange factor 1(ARHGEF1) ,partial - CSB-YP856434HU CSB-EP856434HU CSB-BP856434HU CSB-MP856434HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

ARHGEF1 (transcript variant 1) - TP321180 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

ARHGEF1 Recombinant Protein Antigen - NBP1-82843PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

ARHGEF1 Protein Lysate - orb333686 from Biorbyt Category Protein Prices $400.00 Sizes 200 μg Species Human

ARHGEF1 Peptide, Human - M34GP00878H from Creative Peptides Category Peptide Source Synthetic. Species Human

ARHGEF1 Protein Lysate - orb333685 from Biorbyt Category Protein Prices $400.00 Sizes 200 μg Species Human

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