STAMBP

Gene Symbol STAMBP
Entrez Gene 10617
Alt Symbol AMSH, MICCAP
Species Human
Gene Type protein-coding
Description STAM binding protein
Other Description STAM-binding protein|associated molecule with the SH3 domain of STAM|endosome-associated ubiquitin isopeptidase
Swissprots D6W5H7 Q3MJE7 B5M0B6 O95630
Accessions AAX88908 CAC36455 CCQ43357 EAW99714 EAW99715 EAW99716 O95630 AF052135 AK023768 BC007682 AAH07682 BC065574 AAH65574 BC101467 AAI01468 BC101469 AAI01470 BF203378 BM478027 BQ929694 CX758449 DB477012 DN919763 DQ892616 ABM83542 DQ895856 ABM86782 DR158757 EU927390 ACH57452 U73522 AAD05037 XM_005264088 XP_005264145 XM_005264091 XP_005264148 XM_011532483 XP_011530785 XM_011532484 XP_011530786 XM_011532485 XP_011530787 XR_939651 NM_006463 NP_006454 NM_201647 NP_964010 NM_213622 NP_998787
Function Zinc metalloprotease that specifically cleaves 'Lys-63'- linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization (By similarity). Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways. {ECO:0000250, ECO:0000269|PubMed:10383417, ECO:0000269|PubMed:11483516, ECO:0000269|PubMed:15314065, ECO:0000269|PubMed:17261583, ECO:0000269|PubMed:23542699}.
Subcellular Location Nucleus. Membrane; Peripheral membrane protein. Cytoplasm. Early endosome.
Tissue Specificity Ubiquitously expressed.
Top Pathways Endocytosis

STAMBP Antibody - 5245 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using STAMBP Antibody.

STAMBP (C-1) - sc-398480 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
STAMBP (C-1): sc-398480. Western blot analysis of STAMBP expression in non-transfected 293T: sc-117752 (A), human STAMBP transfected 293T: sc-117052 (B), K-562 (C), HEL 92.1.7 (D), A549 (E) and Jurkat (F) whole cell lysates.

STAMBP (F-1) - sc-393408 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
STAMBP (F-1): sc-393408. Western blot analysis of STAMBP expression in non-transfected 293T: sc-117752 (A), human STAMBP transfected 293T: sc-159791 (B), K-562 (C), HEL 92.1.7 (D), NIH/3T3 (E) and HeLa (F) whole cell lysates.

STAMBP (H-3) - sc-166565 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
STAMBP (H-3): sc-166565. Western blot analysis of STAMBP expression in non-transfected: sc-117752 (A) and human STAMBP transfected: sc-159791 (B) 293T whole cell lysates.

STAMBP (H-4) - sc-271641 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
STAMBP (H-4): sc-271641. Western blot analysis of STAMBP expression in NIH/3T3 whole cell lysate.

STAMBP (H-110) - sc-98765 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
STAMBP (H-110): sc-98765. Western blot analysis of STAMBP expression in HeLa whole cell lysate.

STAMBP (E-17) - sc-109051 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
STAMBP (E-17): sc-109051. Western blot analysis of STAMBP expression in non-transfected: sc-117752 (A) and human STAMBP transfected: sc-117052 (B) 293T whole cell lysates.

STAMBP (M-140) - sc-98766 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
STAMBP (M-140): sc-98766. Western blot analysis of STAMBP expression in HeLa whole cell lysate.

STAMBP (N-12) - sc-109053 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
STAMBP (N-12): sc-109053. Western blot analysis of STAMBP expression in non-transfected: sc-117752 (A) and human STAMBP transfected: sc-117052 (B) 293T whole cell lysates.

Anti-AMSH antibody - ab65281 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-AMSH antibody (ab65281) at 1 µg/mlLane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell LysateLane 2 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell LysateLane 3 : Colon (Rat) Tissue Lysate Lane 4 : SW480 (Human colon adenocarcinoma cell line) Whole Cell Lysate (ab3957)Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutionPerformed under reducing conditions.

Anti-AMSH antibody - ab81217 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-AMSH antibody (ab81217) at 1 µg/ml (in 5% skim milk / PBS buffer) + Jurkat cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-AMSH antibody - ab113053 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-AMSH antibody (ab113053) at 1/100 dilution + A549 cell line lysates at 35 µg

Anti-AMSH antibody - ab168644 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-AMSH antibody (ab168644) at 1 µg/mlLane 1 : AMSH transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysate Lysates/proteins at 15 µl per lane.developed using the ECL technique

Anti-AMSH antibody [EPR4361] - ab108301 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4361
All lanes : Anti-AMSH antibody [EPR4361] (ab108301) at 1/1000 dilutionLane 1 : Jurkat cell lysateLane 2 : HeLa cell lysateLane 3 : Raji cell lysateLane 4 : SW480 cell lysateLysates/proteins at 10 µg per lane.Performed under reducing conditions.

Anti-AMSH antibody - N-terminal - ab151475 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry analysis of paraffin-embedded Human breast ca tissue labeling AMSH with ab151475 at 1/500.

Anti-STAMBP / AMSH Antibody (Internal, clone EPR4361) - LS-C138014 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4361
Western blot analysis on (A) Jurkat, (B) HeLa, (C) Raji, and (D) SW480 cell lysates using anti-AMSH antibody.

Anti-STAMBP / AMSH Antibody (C-Terminus) - LS-C146345 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
STAMBP antibody LS-C146345 Western blot of Jurkat Cell lysate. Antibody concentration 1 ug/ml.

Anti-STAMBP / AMSH Antibody (aa362-391, AP) - LS-C241315 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-STAMBP / AMSH Antibody (aa362-391, APC) - LS-C241316 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-STAMBP / AMSH Antibody (aa362-391, Biotin) - LS-C241317 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-STAMBP / AMSH Antibody (N-Terminus) - LS-C81739 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Jurkat cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-STAMBP / AMSH Antibody (aa362-391, FITC) - LS-C241318 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-STAMBP / AMSH Antibody (aa362-391, Azide-free, HRP) - LS-C248262 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-STAMBP / AMSH Antibody (aa362-391, PE) - LS-C241319 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-STAMBP / AMSH Antibody (aa166-406, FITC) - LS-C301484 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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