STAMBP

Gene Symbol	STAMBP
Entrez Gene	10617
Alt Symbol	AMSH, MICCAP
Species	Human
Gene Type	protein-coding
Description	STAM binding protein
Other Description	STAM-binding protein|associated molecule with the SH3 domain of STAM|endosome-associated ubiquitin isopeptidase
Swissprots	D6W5H7 Q3MJE7 B5M0B6 O95630
Accessions	AAX88908 CAC36455 CCQ43357 EAW99714 EAW99715 EAW99716 O95630 AF052135 AK023768 BC007682 AAH07682 BC065574 AAH65574 BC101467 AAI01468 BC101469 AAI01470 BF203378 BM478027 BQ929694 CX758449 DB477012 DN919763 DQ892616 ABM83542 DQ895856 ABM86782 DR158757 EU927390 ACH57452 U73522 AAD05037 XM_005264088 XP_005264145 XM_005264091 XP_005264148 XM_011532483 XP_011530785 XM_011532484 XP_011530786 XM_011532485 XP_011530787 XR_939651 NM_006463 NP_006454 NM_201647 NP_964010 NM_213622 NP_998787
Function	Zinc metalloprotease that specifically cleaves 'Lys-63'- linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization (By similarity). Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways. {ECO:0000250, ECO:0000269|PubMed:10383417, ECO:0000269|PubMed:11483516, ECO:0000269|PubMed:15314065, ECO:0000269|PubMed:17261583, ECO:0000269|PubMed:23542699}.
Subcellular Location	Nucleus. Membrane; Peripheral membrane protein. Cytoplasm. Early endosome.
Tissue Specificity	Ubiquitously expressed.
Top Pathways	Endocytosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human AMSH full length protein - ab188712 from Abcam Category Protein Prices $572.00 Sizes 50 µg Source Baculovirus infected Sf21 cells Species Human

Active human AMSH full length protein - ab188715 from Abcam Category Protein Prices $572.00 Sizes 50 µg Source Baculovirus infected Sf21 cells Species Human

Active human AMSH protein fragment - ab125745 from Abcam Category Protein Source E. coli Species Human

Human AMSH full length protein - ab132706 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Human AMSH full length protein - ab139803 from Abcam Category Protein Prices $297.00 Sizes 100 µg Source E. coli Species Human

Human AMSH peptide - ab74470 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

STAMBP / AMSH Antibody Blocking Peptide - LS-E1870 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

STAMBP / AMSH Antibody Blocking Peptide - LS-E19331 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

STAMBP / AMSH Antibody Blocking Peptide - LS-E19332 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

AMSH/STAMBP Recombinant Protein - H00010617-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human AMSH/STAMBP Protein - NBP2-22825 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

STAMBP-Antibody-C-term-Blocking-peptide - BP12698b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human AMSH/STAMBP (Sf 21-expressed), CF - E-548B-050 from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (baculovirus)-derived,

Recombinant Human GST-AMSH/STAMBP, CF - E-549-050 from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (baculovirus)-derived, Contains an N-terminal GST (glutathione S-transferase) tag

STAMBP Blocking Peptide - 33R-8355 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

STAMBP protein (His tag) - 80R-2627 from Fitzgerald Category Protein Prices $270.00 Sizes 100 µg Source E.coli

Human STAM Binding Protein Protein - abx069166 from Abbexa Category Protein Source E.coli Species Human

STAMBP (1-424, His-tag) - AR50747PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

STAMBP (1-424, His-tag) - AR50747PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

STAMBP - H00010617-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

STAMBP - H00010617-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

STAM Binding Protein (STAMBP), Human - 20-9231 from ARP American Research Products Category Protein Prices $467.00 Sizes 50 µg Source E.coli Species Human

STAMBP, 1-424aa Human, His tag, E.coli - 01-P1923 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

STAMBP fusion protein - Ag1895 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PKG Species Human

STAMBP, 1-424aa Human, His tag, E.coli - GWB-PPST11 from Genway Biotech Category Protein Prices $300.00, $900.00 Sizes 100 μg, 500 μg Source E.coli Species Human

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