| Gene Symbol | STAMBP |
|---|---|
| Entrez Gene | 10617 |
| Alt Symbol | AMSH, MICCAP |
| Species | Human |
| Gene Type | protein-coding |
| Description | STAM binding protein |
| Other Description | STAM-binding protein|associated molecule with the SH3 domain of STAM|endosome-associated ubiquitin isopeptidase |
| Swissprots | D6W5H7 Q3MJE7 B5M0B6 O95630 |
| Accessions | AAX88908 CAC36455 CCQ43357 EAW99714 EAW99715 EAW99716 O95630 AF052135 AK023768 BC007682 AAH07682 BC065574 AAH65574 BC101467 AAI01468 BC101469 AAI01470 BF203378 BM478027 BQ929694 CX758449 DB477012 DN919763 DQ892616 ABM83542 DQ895856 ABM86782 DR158757 EU927390 ACH57452 U73522 AAD05037 XM_005264088 XP_005264145 XM_005264091 XP_005264148 XM_011532483 XP_011530785 XM_011532484 XP_011530786 XM_011532485 XP_011530787 XR_939651 NM_006463 NP_006454 NM_201647 NP_964010 NM_213622 NP_998787 |
| Function | Zinc metalloprotease that specifically cleaves 'Lys-63'- linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization (By similarity). Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways. {ECO:0000250, ECO:0000269|PubMed:10383417, ECO:0000269|PubMed:11483516, ECO:0000269|PubMed:15314065, ECO:0000269|PubMed:17261583, ECO:0000269|PubMed:23542699}. |
| Subcellular Location | Nucleus. Membrane; Peripheral membrane protein. Cytoplasm. Early endosome. |
| Tissue Specificity | Ubiquitously expressed. |
| Top Pathways | Endocytosis |