STAMBP

Gene Symbol STAMBP
Entrez Gene 10617
Alt Symbol AMSH, MICCAP
Species Human
Gene Type protein-coding
Description STAM binding protein
Other Description STAM-binding protein|associated molecule with the SH3 domain of STAM|endosome-associated ubiquitin isopeptidase
Swissprots D6W5H7 Q3MJE7 B5M0B6 O95630
Accessions AAX88908 CAC36455 CCQ43357 EAW99714 EAW99715 EAW99716 O95630 AF052135 AK023768 BC007682 AAH07682 BC065574 AAH65574 BC101467 AAI01468 BC101469 AAI01470 BF203378 BM478027 BQ929694 CX758449 DB477012 DN919763 DQ892616 ABM83542 DQ895856 ABM86782 DR158757 EU927390 ACH57452 U73522 AAD05037 XM_005264088 XP_005264145 XM_005264091 XP_005264148 XM_011532483 XP_011530785 XM_011532484 XP_011530786 XM_011532485 XP_011530787 XR_939651 NM_006463 NP_006454 NM_201647 NP_964010 NM_213622 NP_998787
Function Zinc metalloprotease that specifically cleaves 'Lys-63'- linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization (By similarity). Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways. {ECO:0000250, ECO:0000269|PubMed:10383417, ECO:0000269|PubMed:11483516, ECO:0000269|PubMed:15314065, ECO:0000269|PubMed:17261583, ECO:0000269|PubMed:23542699}.
Subcellular Location Nucleus. Membrane; Peripheral membrane protein. Cytoplasm. Early endosome.
Tissue Specificity Ubiquitously expressed.
Top Pathways Endocytosis

STAMBP CRISPR/Cas9 KO Plasmid (h) - sc-404726 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

STAMBP HDR Plasmid (h) - sc-404726-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

STAMBP Double Nickase Plasmid (h) - sc-404726-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

STAMBP Double Nickase Plasmid (h2) - sc-404726-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

STAMBP CRISPR Activation Plasmid (h) - sc-404726-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

STAMBP CRISPR Activation Plasmid (h2) - sc-404726-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

STAMBP Lentiviral Activation Particles (h) - sc-404726-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

STAMBP Lentiviral Activation Particles (h2) - sc-404726-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

STAMBP siRNA (h) - sc-94512 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

STAMBP shRNA Plasmid (h) - sc-94512-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

STAMBP shRNA (h) Lentiviral Particles - sc-94512-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

AMSH/STAMBP RNAi - H00010617-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

AMSH/STAMBP RNAi - H00010617-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU103311 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

MISSION® esiRNA - EHU094781 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN20694 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20694 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR05135 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr05135

STAMBP siRNA (Human) - CRH7230 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

AMSH/STAMBP RNAi - H00010617-R03 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

STAMBP - MBS8225521 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human STAMBP (NM_006463.4) - SHH419208 from Creative biogene

Category siRNA
Species Reactivities Human

STAMBP shRNA Plasmid (Human) - CHH7230 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

STAMBP miRNA 3'UTR clone - MiUTR3H-08307 from Creative biogene

Species Reactivities Human

STAMBP miRNA 3'UTR clone - MiUTR3H-08308 from Creative biogene

Species Reactivities Human
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