Gene Symbol | HLTF |
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Entrez Gene | 6596 |
Alt Symbol | HIP116, HIP116A, HLTF1, RNF80, SMARCA3, SNF2L3, ZBU1 |
Species | Human |
Gene Type | protein-coding |
Description | helicase-like transcription factor |
Other Description | DNA-binding protein/plasminogen activator inhibitor 1 regulator|DNA-binding protein/plasminogen activator inhibitor-1 regulator|RING finger protein 80|SNF2-like 3|SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 3|SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3|sucrose nonfermenting protein 2-like 3|sucrose nonfermenting-like 3 |
Swissprots | Q14536 Q86YA5 Q7KYJ6 Q92652 Q14527 Q96KM9 D3DNH3 Q16051 |
Accessions | CAD10805 EAW78889 EAW78890 EAW78891 EAW78892 EAW78893 Q14527 AB209052 BAD92289 AI971472 AK291231 BAF83920 BC005260 AAH05260 BC014326 BC015498 AAH15498 BC030976 AAH30976 BC044659 AAH44659 EU446704 ABZ92233 L34673 AAA67436 S64671 AAB27691 XM_005247724 XP_005247781 XM_011513091 XP_011511393 XM_011513092 XP_011511394 XM_011513093 XP_011511395 NM_003071 NP_003062 NM_139048 NP_620636 |
Function | Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA. {ECO:0000250, ECO:0000269|PubMed:10391891, ECO:0000269|PubMed:18316726, ECO:0000269|PubMed:18719106, ECO:0000269|PubMed:7876228, ECO:0000269|PubMed:8672239, ECO:0000269|PubMed:9126292}. |
Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000269|PubMed:8672239}. Nucleus, nucleolus {ECO:0000250}. Nucleus, nucleoplasm {ECO:0000250}. Note=Nuclear localization is stimulated by progesterone. {ECO:0000250}. |
Tissue Specificity | Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle. {ECO:0000269|PubMed:8672239, ECO:0000269|PubMed:9126292}. |
Helicase Like Transcription Factor, HLTF, Human, ELISA Kit - E-EL-H1512 from ARP American Research Products
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Helicase Like Transcription Factor, HLTF, Mouse, ELISA Kit - E-EL-M0625 from ARP American Research Products
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Helicase Like Transcription Factor, HLTF, Rat, ELISA Kit - E-EL-R0486 from ARP American Research Products
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Helicase Like Transcription Factor, HLTF, Rabbit, ELISA Kit - E-EL-RB1046 from ARP American Research Products
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Helicase Like Transcription Factor, HLTF, Chicken, ELISA Kit - E-EL-Ch0981 from ARP American Research Products
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Helicase Like Transcription Factor, HLTF, Porcine, ELISA Kit - E-EL-P1283 from ARP American Research Products
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Helicase Like Transcription Factor, HLTF, Guinea Pig, ELISA Kit - E-EL-GP1116 from ARP American Research Products
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Helicase Like Transcription Factor, HLTF, Monkey, ELISA Kit - E-EL-MK1756 from ARP American Research Products
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Human HLTF(Helicase Like Transcription Factor) ELISA Kit - E-EL-H1512 from Elabscience
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helicase-like transcription factor, ELISA Kit - MBS9336465 from MyBioSource
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HLTF, ELISA Kit - MBS2515490 from MyBioSource
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HLTF, ELISA Kit - MBS2509893 from MyBioSource
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HLTF, ELISA Kit - MBS2512719 from MyBioSource
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HLTF, ELISA Kit - MBS2507094 from MyBioSource
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HLTF, ELISA Kit - MBS2511484 from MyBioSource
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HLTF, ELISA Kit - MBS2501831 from MyBioSource
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HLTF, ELISA Kit - MBS2511303 from MyBioSource
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HLTF, ELISA Kit - MBS2504663 from MyBioSource
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Human UCP-2(Uncoupling Protein 2, Mitochondrial) ELISA Kit - E-EL-H1512 from Iwai North America Inc.
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Human HLTF ELISA Kit - E018869 from Biobool
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anti-SMARCA3 antibody - ARG63223 from Arigo Biolaboratories
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HLTF ELISA Kit (Human) (OKEI00247) - OKEI00247 from Aviva Systems Biology
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Mouse SMARCA3 / HLTF ELISA Kit (Sandwich ELISA) - LS-F38347 from LifeSpan Bioscience
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Rat SMARCA3 / HLTF ELISA Kit (Sandwich ELISA) - LS-F38647 from LifeSpan Bioscience
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Human SMARCA3 / HLTF ELISA Kit (Sandwich ELISA) - LS-F37970 from LifeSpan Bioscience
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