HLTF

Gene Symbol	HLTF
Entrez Gene	6596
Alt Symbol	HIP116, HIP116A, HLTF1, RNF80, SMARCA3, SNF2L3, ZBU1
Species	Human
Gene Type	protein-coding
Description	helicase-like transcription factor
Other Description	DNA-binding protein/plasminogen activator inhibitor 1 regulator|DNA-binding protein/plasminogen activator inhibitor-1 regulator|RING finger protein 80|SNF2-like 3|SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 3|SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3|sucrose nonfermenting protein 2-like 3|sucrose nonfermenting-like 3
Swissprots	Q14536 Q86YA5 Q7KYJ6 Q92652 Q14527 Q96KM9 D3DNH3 Q16051
Accessions	CAD10805 EAW78889 EAW78890 EAW78891 EAW78892 EAW78893 Q14527 AB209052 BAD92289 AI971472 AK291231 BAF83920 BC005260 AAH05260 BC014326 BC015498 AAH15498 BC030976 AAH30976 BC044659 AAH44659 EU446704 ABZ92233 L34673 AAA67436 S64671 AAB27691 XM_005247724 XP_005247781 XM_011513091 XP_011511393 XM_011513092 XP_011511394 XM_011513093 XP_011511395 NM_003071 NP_003062 NM_139048 NP_620636
Function	Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA. {ECO:0000250, ECO:0000269|PubMed:10391891, ECO:0000269|PubMed:18316726, ECO:0000269|PubMed:18719106, ECO:0000269|PubMed:7876228, ECO:0000269|PubMed:8672239, ECO:0000269|PubMed:9126292}.
Subcellular Location	Cytoplasm {ECO:0000250}. Nucleus {ECO:0000269|PubMed:8672239}. Nucleus, nucleolus {ECO:0000250}. Nucleus, nucleoplasm {ECO:0000250}. Note=Nuclear localization is stimulated by progesterone. {ECO:0000250}.
Tissue Specificity	Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle. {ECO:0000269|PubMed:8672239, ECO:0000269|PubMed:9126292}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human HLTF peptide - ab22937 from Abcam Category Peptide Species Human

Human HLTF protein fragment - ab152692 from Abcam Category Protein Source Wheat germ Species Human

SMARCA3 / HLTF Antibody Blocking Peptide - LS-E12247 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SMARCA3 / HLTF Antibody Blocking Peptide - LS-E25361 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SMARCA3 / HLTF Antibody Blocking Peptide - LS-E13726 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SMARCA3 / HLTF Antibody Blocking Peptide - LS-E13725 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SMARCA3 / HLTF Antibody Blocking Peptide - LS-E8479 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human HLTF Protein - H00006596-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

HIP116A-Antibody-Center-Blocking-Peptide - BP6812c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

HLTF blocking peptide - GTX89908-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat, Bovine

HLTF Blocking Peptide - 33R-8942 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SMARCA3 Blocking Peptide - 33R-2938 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SMARCA3 Blocking Peptide - 33R-2121 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

HLTF Peptide - AC21-0188-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

SMARCA3 / HLTF - H00006596-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SMARCA3 / HLTF - H00006596-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

SMARCA3 Peptide - 46-385P from ProSci Category Peptide Species Human

HLTF fusion protein - ag5596 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Helicase Like Transcription Factor (HLTF) - RPC529Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Helicase Like Transcription Factor (HLTF) - RPC529Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Helicase Like Transcription Factor (HLTF) - RPC529Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Helicase-like transcription factor(HLTF) ,partial - CSB-YP010520HU CSB-EP010520HU CSB-BP010520HU CSB-MP010520HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

HLTF Protein - abx165011 from Abbexa Category Protein Species Human, Mouse, Rat

HLTF Protein - abx163203 from Abbexa Category Protein Species Human

SMARCA3, Peptide - MBS426126 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Dog, Bovine

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