HLTF

Gene Symbol HLTF
Entrez Gene 6596
Alt Symbol HIP116, HIP116A, HLTF1, RNF80, SMARCA3, SNF2L3, ZBU1
Species Human
Gene Type protein-coding
Description helicase-like transcription factor
Other Description DNA-binding protein/plasminogen activator inhibitor 1 regulator|DNA-binding protein/plasminogen activator inhibitor-1 regulator|RING finger protein 80|SNF2-like 3|SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 3|SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3|sucrose nonfermenting protein 2-like 3|sucrose nonfermenting-like 3
Swissprots Q14536 Q86YA5 Q7KYJ6 Q92652 Q14527 Q96KM9 D3DNH3 Q16051
Accessions CAD10805 EAW78889 EAW78890 EAW78891 EAW78892 EAW78893 Q14527 AB209052 BAD92289 AI971472 AK291231 BAF83920 BC005260 AAH05260 BC014326 BC015498 AAH15498 BC030976 AAH30976 BC044659 AAH44659 EU446704 ABZ92233 L34673 AAA67436 S64671 AAB27691 XM_005247724 XP_005247781 XM_011513091 XP_011511393 XM_011513092 XP_011511394 XM_011513093 XP_011511395 NM_003071 NP_003062 NM_139048 NP_620636
Function Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA. {ECO:0000250, ECO:0000269|PubMed:10391891, ECO:0000269|PubMed:18316726, ECO:0000269|PubMed:18719106, ECO:0000269|PubMed:7876228, ECO:0000269|PubMed:8672239, ECO:0000269|PubMed:9126292}.
Subcellular Location Cytoplasm {ECO:0000250}. Nucleus {ECO:0000269|PubMed:8672239}. Nucleus, nucleolus {ECO:0000250}. Nucleus, nucleoplasm {ECO:0000250}. Note=Nuclear localization is stimulated by progesterone. {ECO:0000250}.
Tissue Specificity Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle. {ECO:0000269|PubMed:8672239, ECO:0000269|PubMed:9126292}.

HLTF CRISPR/Cas9 KO Plasmid (h) - sc-405139 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HLTF HDR Plasmid (h) - sc-405139-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HLTF Double Nickase Plasmid (h) - sc-405139-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HLTF Double Nickase Plasmid (h2) - sc-405139-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HLTF CRISPR Activation Plasmid (h) - sc-405139-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HLTF CRISPR Activation Plasmid (h2) - sc-405139-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HLTF Lentiviral Activation Particles (h) - sc-405139-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HLTF Lentiviral Activation Particles (h2) - sc-405139-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HLTF siRNA (h) - sc-45943 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HLTF shRNA Plasmid (h) - sc-45943-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HLTF shRNA (h) Lentiviral Particles - sc-45943-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HLTF RNAi - H00006596-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU092571 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN10151 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10151 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR13210 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr13210

HLTF siRNA (Human) - CRH4480 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

HLTF RNAi - H00006596-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

HLTF - MBS8224694 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human HLTF (NM_003071.3) - SHH313149 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human HLTF(NM_003071.3) - SHH124517 from Creative biogene

Category siRNA
Species Reactivities Human

Human HLTF siRNA - orb264982 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

HLTF shRNA Plasmid (Human) - CHH4480 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

HLTF miRNA 3'UTR clone - MiUTR1H-04591 from Creative biogene

Species Reactivities Human

HLTF miRNA 3'UTR clone - MiUTR3H-05821 from Creative biogene

Species Reactivities Human
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