| Gene Symbol |
HLTF
|
| Entrez Gene |
6596
|
| Alt Symbol |
HIP116, HIP116A, HLTF1, RNF80, SMARCA3, SNF2L3, ZBU1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
helicase-like transcription factor
|
| Other Description |
DNA-binding protein/plasminogen activator inhibitor 1 regulator|DNA-binding protein/plasminogen activator inhibitor-1 regulator|RING finger protein 80|SNF2-like 3|SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 3|SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3|sucrose nonfermenting protein 2-like 3|sucrose nonfermenting-like 3
|
| Swissprots |
Q14536 Q86YA5 Q7KYJ6 Q92652 Q14527 Q96KM9 D3DNH3 Q16051
|
| Accessions |
CAD10805 EAW78889 EAW78890 EAW78891 EAW78892 EAW78893 Q14527 AB209052 BAD92289 AI971472 AK291231 BAF83920 BC005260 AAH05260 BC014326 BC015498 AAH15498 BC030976 AAH30976 BC044659 AAH44659 EU446704 ABZ92233 L34673 AAA67436 S64671 AAB27691 XM_005247724 XP_005247781 XM_011513091 XP_011511393 XM_011513092 XP_011511394 XM_011513093 XP_011511395 NM_003071 NP_003062 NM_139048 NP_620636
|
| Function |
Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA. {ECO:0000250, ECO:0000269|PubMed:10391891, ECO:0000269|PubMed:18316726, ECO:0000269|PubMed:18719106, ECO:0000269|PubMed:7876228, ECO:0000269|PubMed:8672239, ECO:0000269|PubMed:9126292}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000269|PubMed:8672239}. Nucleus, nucleolus {ECO:0000250}. Nucleus, nucleoplasm {ECO:0000250}. Note=Nuclear localization is stimulated by progesterone. {ECO:0000250}.
|
| Tissue Specificity |
Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle. {ECO:0000269|PubMed:8672239, ECO:0000269|PubMed:9126292}.
|