| Gene Symbol |
AGBL4
|
| Entrez Gene |
84871
|
| Alt Symbol |
CCP6
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ATP/GTP binding protein-like 4
|
| Other Description |
ATP/GTP-binding protein-like 4|cytosolic carboxypeptidase 6
|
| Swissprots |
B4DG37 B3KT26 Q5VU57
|
| Accessions |
EAX06847 Q5VU57 AF075049 AK027348 BAB55053 AK094826 BAG52938 AK294394 BAG57648 AK294633 BAG57812 AK296221 BAG58944 BC035739 BC126383 AAI26384 BC144171 XM_006710986 XP_006711049 XM_011542308 XP_011540610 XM_011542309 XP_011540611 XM_011542310 XP_011540612 XM_011542311 XP_011540613 NM_032785 NP_116174
|
| Function |
Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5. {ECO:0000250|UniProtKB:Q09LZ8}.
|
| Subcellular Location |
Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q09LZ8}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:23085998}. Golgi apparatus {ECO:0000269|PubMed:23085998}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:23085998}. Note=Colocalizes with gamma-tubulin in the centrioles at interphase and dividing cells and with glutamylated tubulin in basal bodies of ciliated cells. {ECO:0000269|PubMed:23085998}.
|