Gene Symbol | AGBL4 |
---|---|
Entrez Gene | 84871 |
Alt Symbol | CCP6 |
Species | Human |
Gene Type | protein-coding |
Description | ATP/GTP binding protein-like 4 |
Other Description | ATP/GTP-binding protein-like 4|cytosolic carboxypeptidase 6 |
Swissprots | B4DG37 B3KT26 Q5VU57 |
Accessions | EAX06847 Q5VU57 AF075049 AK027348 BAB55053 AK094826 BAG52938 AK294394 BAG57648 AK294633 BAG57812 AK296221 BAG58944 BC035739 BC126383 AAI26384 BC144171 XM_006710986 XP_006711049 XM_011542308 XP_011540610 XM_011542309 XP_011540611 XM_011542310 XP_011540612 XM_011542311 XP_011540613 NM_032785 NP_116174 |
Function | Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5. {ECO:0000250|UniProtKB:Q09LZ8}. |
Subcellular Location | Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q09LZ8}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:23085998}. Golgi apparatus {ECO:0000269|PubMed:23085998}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:23085998}. Note=Colocalizes with gamma-tubulin in the centrioles at interphase and dividing cells and with glutamylated tubulin in basal bodies of ciliated cells. {ECO:0000269|PubMed:23085998}. |