| Gene Symbol |
RHEB
|
| Entrez Gene |
6009
|
| Alt Symbol |
RHEB2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Ras homolog enriched in brain
|
| Other Description |
GTP-binding protein Rheb|Ras homolog enriched in brain 2
|
| Swissprots |
Q99444 B3KWN6 D3DX13 Q53Y56 Q15382
|
| Accessions |
AAD15548 CDL93493 EAL24515 EAW53986 EAW53987 EAW53988 EAW53989 Q15382 AF148645 AAF73125 AF493921 AAM12635 AK125446 BAG54198 AK289370 BAF82059 BC009638 BC016155 AAH16155 BC066307 AAH66307 BC107705 AAI07706 BG702213 BM670621 BT006958 AAP35604 D78132 BAA11211 DA475169 Z29677 CAA82774 XM_011516457 XP_011514759 NM_005614 NP_005605
|
| Function |
Activates the protein kinase activity of mTORC1, and thereby plays a role in the regulation of apoptosis. Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Has low intrinsic GTPase activity. {ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12869586, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:15854902, ECO:0000269|PubMed:16098514, ECO:0000269|PubMed:20381137}.
|
| Subcellular Location |
Endomembrane system {ECO:0000269|PubMed:22002721, ECO:0000305}; Lipid-anchor {ECO:0000269|PubMed:22002721, ECO:0000305}; Cytoplasmic side {ECO:0000269|PubMed:15489334, ECO:0000305}. Golgi apparatus membrane {ECO:0000269|PubMed:22002721}; Lipid-anchor {ECO:0000305|PubMed:22002721}; Cytoplasmic side {ECO:0000305|PubMed:22002721}. Cytoplasm, cytosol {ECO:0000269|PubMed:22002721}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:22002721}; Lipid-anchor {ECO:0000269|PubMed:22002721}; Cytoplasmic side {ECO:0000269|PubMed:22002721}.
|
| Tissue Specificity |
Ubiquitous. Highest levels observed in skeletal and cardiac muscle. {ECO:0000269|PubMed:8543055}.
|
| Top Pathways |
Insulin signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Choline metabolism in cancer, mTOR signaling pathway
|
