RHEB

Gene Symbol	RHEB
Entrez Gene	6009
Alt Symbol	RHEB2
Species	Human
Gene Type	protein-coding
Description	Ras homolog enriched in brain
Other Description	GTP-binding protein Rheb\|Ras homolog enriched in brain 2
Swissprots	Q99444 B3KWN6 D3DX13 Q53Y56 Q15382
Accessions	AAD15548 CDL93493 EAL24515 EAW53986 EAW53987 EAW53988 EAW53989 Q15382 AF148645 AAF73125 AF493921 AAM12635 AK125446 BAG54198 AK289370 BAF82059 BC009638 BC016155 AAH16155 BC066307 AAH66307 BC107705 AAI07706 BG702213 BM670621 BT006958 AAP35604 D78132 BAA11211 DA475169 Z29677 CAA82774 XM_011516457 XP_011514759 NM_005614 NP_005605
Function	Activates the protein kinase activity of mTORC1, and thereby plays a role in the regulation of apoptosis. Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Has low intrinsic GTPase activity. {ECO:0000269\|PubMed:12271141, ECO:0000269\|PubMed:12869586, ECO:0000269\|PubMed:15340059, ECO:0000269\|PubMed:15854902, ECO:0000269\|PubMed:16098514, ECO:0000269\|PubMed:20381137}.
Subcellular Location	Endomembrane system {ECO:0000269\|PubMed:22002721, ECO:0000305}; Lipid-anchor {ECO:0000269\|PubMed:22002721, ECO:0000305}; Cytoplasmic side {ECO:0000269\|PubMed:15489334, ECO:0000305}. Golgi apparatus membrane {ECO:0000269\|PubMed:22002721}; Lipid-anchor {ECO:0000305\|PubMed:22002721}; Cytoplasmic side {ECO:0000305\|PubMed:22002721}. Cytoplasm, cytosol {ECO:0000269\|PubMed:22002721}. Endoplasmic reticulum membrane {ECO:0000269\|PubMed:22002721}; Lipid-anchor {ECO:0000269\|PubMed:22002721}; Cytoplasmic side {ECO:0000269\|PubMed:22002721}.
Tissue Specificity	Ubiquitous. Highest levels observed in skeletal and cardiac muscle. {ECO:0000269\|PubMed:8543055}.
Top Pathways	Insulin signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Choline metabolism in cancer, mTOR signaling pathway

SignalSilence ® Rheb siRNA II - 14284 from Cell Signaling Technology

Category	siRNA
Prices	$256.00
Sizes	300 µl (100 transfections)
Species Reactivities	Human

Western blot analysis of extracts from A549 cells, untransfected, transfected with 100 nM SignalSilence ® Control siRNA (Unconjugated) #6568 (-), SignalSilence ® Rheb siRNA I #14267 (+), or SignalSilence ® Rheb siRNA II (+), using Rheb (E1G1R) Rabbit mAb #13879 (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower). The Rheb (E1G1R) Rabbit mAb confirms silencing of Rheb expression, while the β-Actin (D6A8) Rabbit mAb is used as a loading control.

SignalSilence ® Rheb siRNA I - 14267 from Cell Signaling Technology

Category	siRNA
Prices	$256.00
Sizes	300 µl (100 transfections)
Species Reactivities	Human

Rheb CRISPR/Cas9 KO Plasmid (h) - sc-400539 from Santa Cruz Biotechnology

Category	CRISPR
Prices	$345.00
Sizes	20 µg
Species Reactivities	Human

Rheb HDR Plasmid (h) - sc-400539-HDR from Santa Cruz Biotechnology

Prices	$345.00
Sizes	20 µg
Species Reactivities	Human

Rheb Double Nickase Plasmid (h) - sc-400539-NIC from Santa Cruz Biotechnology

Prices	$345.00
Sizes	20 µg
Species Reactivities	Human

Rheb Double Nickase Plasmid (h2) - sc-400539-NIC-2 from Santa Cruz Biotechnology

Prices	$345.00
Sizes	20 µg
Species Reactivities	Human

Rheb CRISPR Activation Plasmid (h) - sc-400539-ACT from Santa Cruz Biotechnology

Category	CRISPR
Prices	$345.00
Sizes	20 µg
Species Reactivities	Human

Rheb CRISPR Activation Plasmid (h2) - sc-400539-ACT-2 from Santa Cruz Biotechnology

Category	CRISPR
Prices	$345.00
Sizes	20 µg
Species Reactivities	Human

Rheb Lentiviral Activation Particles (h) - sc-400539-LAC from Santa Cruz Biotechnology

Prices	$345.00
Sizes	20 µg
Species Reactivities	Human

Rheb Lentiviral Activation Particles (h2) - sc-400539-LAC-2 from Santa Cruz Biotechnology

Prices	$345.00
Sizes	20 µg
Species Reactivities	Human

Rheb siRNA (h) - sc-41859 from Santa Cruz Biotechnology

Category	siRNA
Prices	$258.00
Sizes	10 µm
Species Reactivities	Human

Rheb shRNA Plasmid (h) - sc-41859-SH from Santa Cruz Biotechnology

Category	siRNA
Prices	$258.00
Sizes	10 µm
Species Reactivities	Human

Rheb shRNA (h) Lentiviral Particles - sc-41859-V from Santa Cruz Biotechnology

Category	siRNA
Prices	$258.00
Sizes	10 µm
Species Reactivities	Human

Rheb RNAi - H00006009-R01 from Novus Biologicals

Category	siRNA
Prices	$399.00
Sizes	20 nmol
Species Reactivities	Human

MISSION® esiRNA - EHU109911 from Sigma-Aldrich

Category	siRNA
Prices	$140.00, $250.00
Sizes	20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN18248 from Sigma-Aldrich

Category	ZFN Kit
Prices	$4,999.00
Sizes	1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18248 from Sigma-Aldrich

Category	ZFN Kit
Prices	$3,999.00
Sizes	1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR08402 from Sigma-Aldrich

Category	miRNA
Prices	$350.00
Sizes	hutr08402

RHEB siRNA (Human) - CRH4076 from Cohesion Biosciences

Category	siRNA
Prices	$340.00, $510.00
Sizes	15 nmol, 30 nmol
Species Reactivities	Human

RHEB - MBS8211715 from MyBioSource

Prices	$365.00, $515.00
Sizes	15 nmol, 30 nmol
Species Reactivities	Human

shRNA set against Human RHEB(NM_005614.3) - SHR180582 from Creative biogene

Category	siRNA
Species Reactivities	Human

Human RHEB siRNA - orb264578 from Biorbyt

Category	siRNA
Prices	$485.00, $629.00
Sizes	15 nmol, 30 nmol
Species Reactivities	Human

RHEB shRNA Plasmid (Human) - CHH4076 from Cohesion Biosciences

Category	siRNA
Prices	$500.00, $750.00
Sizes	150 µg, 300 µg
Species Reactivities	Human

RHEB miRNA 3'UTR clone - MiUTR1H-08807 from Creative biogene

Species Reactivities	Human

Search more