RHEB

Gene Symbol	RHEB
Entrez Gene	6009
Alt Symbol	RHEB2
Species	Human
Gene Type	protein-coding
Description	Ras homolog enriched in brain
Other Description	GTP-binding protein Rheb|Ras homolog enriched in brain 2
Swissprots	Q99444 B3KWN6 D3DX13 Q53Y56 Q15382
Accessions	AAD15548 CDL93493 EAL24515 EAW53986 EAW53987 EAW53988 EAW53989 Q15382 AF148645 AAF73125 AF493921 AAM12635 AK125446 BAG54198 AK289370 BAF82059 BC009638 BC016155 AAH16155 BC066307 AAH66307 BC107705 AAI07706 BG702213 BM670621 BT006958 AAP35604 D78132 BAA11211 DA475169 Z29677 CAA82774 XM_011516457 XP_011514759 NM_005614 NP_005605
Function	Activates the protein kinase activity of mTORC1, and thereby plays a role in the regulation of apoptosis. Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Has low intrinsic GTPase activity. {ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12869586, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:15854902, ECO:0000269|PubMed:16098514, ECO:0000269|PubMed:20381137}.
Subcellular Location	Endomembrane system {ECO:0000269|PubMed:22002721, ECO:0000305}; Lipid-anchor {ECO:0000269|PubMed:22002721, ECO:0000305}; Cytoplasmic side {ECO:0000269|PubMed:15489334, ECO:0000305}. Golgi apparatus membrane {ECO:0000269|PubMed:22002721}; Lipid-anchor {ECO:0000305|PubMed:22002721}; Cytoplasmic side {ECO:0000305|PubMed:22002721}. Cytoplasm, cytosol {ECO:0000269|PubMed:22002721}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:22002721}; Lipid-anchor {ECO:0000269|PubMed:22002721}; Cytoplasmic side {ECO:0000269|PubMed:22002721}.
Tissue Specificity	Ubiquitous. Highest levels observed in skeletal and cardiac muscle. {ECO:0000269|PubMed:8543055}.
Top Pathways	Insulin signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Choline metabolism in cancer, mTOR signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human RHEB peptide - ab39861 from Abcam Category Peptide Prices $181.00 Sizes 50 µg Species Human

Active RHEB peptide - ab39862 from Abcam Category Peptide Prices $181.00 Sizes 50 µg

Human RHEB (mutated D60 K) protein fragment - ab176614 from Abcam Category Protein Source E. coli Species Human

Human RHEB full length protein - ab173075 from Abcam Category Protein Source E. coli Species Human

Human RHEB full length protein - ab56271 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

Human RHEB full length protein - ab78768 from Abcam Category Protein Source E. coli Species Human

Human RHEB full length protein - ab91341 from Abcam Category Protein Source E. coli Species Human

Human RHEB peptide - ab194764 from Abcam Category Peptide Species Human

Human RHEB protein fragment - ab176680 from Abcam Category Protein Source E. coli Species Human

RHEB Antibody Blocking Peptide - LS-E1203 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RHEB Antibody Blocking Peptide - LS-E30136 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

RHEB Antibody Blocking Peptide - LS-E30137 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Rheb Recombinant Protein - H00006009-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human Rheb Protein - NBC1-18435 from Novus Biologicals Category Protein Prices $229.00 Sizes 100 µg Source E.coli Species Human

Rheb Blocking Peptide - NBP1-77214PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

Rheb Blocking Peptide - NBP1-76432PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

RHEB-Antibody-C-term-Blocking-peptide - BP11767b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Rheb Protein - GTX108597-pro from GeneTex Category Protein Prices $299.00 Sizes 25 μg Source E. coli Species Human

RHEB Protein (OPPA01224) - OPPA01224 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 10 µg Source E. Coli

Human RHEB R protein - orb163538 from Biorbyt Category Protein Prices $408.00, $595.00, $2,074.00, $2,933.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Source E. coli Species Human

Rheb protein - orb85053 from Biorbyt Category Protein Prices $383.00 Sizes 50 μg Source NM_005614 Species Human

Human Ras Homolog Enriched in Brain protein - orb81318 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 10 μg, 50 μg Source E.coli

Human RHEB protein (His Tag) - orb139590 from Biorbyt Category Protein Prices $323.00, $434.00 Sizes 50 μg, 100 μg Source Baculovirus-Insect Cells Species Human

RHEB Blocking Peptide - 33R-9564 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

RheB protein (T7 tag) - 80R-1076 from Fitzgerald Category Protein Prices $180.00 Sizes 100 µg Source E.coli

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