RHEB

Gene Symbol	RHEB
Entrez Gene	6009
Alt Symbol	RHEB2
Species	Human
Gene Type	protein-coding
Description	Ras homolog enriched in brain
Other Description	GTP-binding protein Rheb|Ras homolog enriched in brain 2
Swissprots	Q99444 B3KWN6 D3DX13 Q53Y56 Q15382
Accessions	AAD15548 CDL93493 EAL24515 EAW53986 EAW53987 EAW53988 EAW53989 Q15382 AF148645 AAF73125 AF493921 AAM12635 AK125446 BAG54198 AK289370 BAF82059 BC009638 BC016155 AAH16155 BC066307 AAH66307 BC107705 AAI07706 BG702213 BM670621 BT006958 AAP35604 D78132 BAA11211 DA475169 Z29677 CAA82774 XM_011516457 XP_011514759 NM_005614 NP_005605
Function	Activates the protein kinase activity of mTORC1, and thereby plays a role in the regulation of apoptosis. Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Has low intrinsic GTPase activity. {ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12869586, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:15854902, ECO:0000269|PubMed:16098514, ECO:0000269|PubMed:20381137}.
Subcellular Location	Endomembrane system {ECO:0000269|PubMed:22002721, ECO:0000305}; Lipid-anchor {ECO:0000269|PubMed:22002721, ECO:0000305}; Cytoplasmic side {ECO:0000269|PubMed:15489334, ECO:0000305}. Golgi apparatus membrane {ECO:0000269|PubMed:22002721}; Lipid-anchor {ECO:0000305|PubMed:22002721}; Cytoplasmic side {ECO:0000305|PubMed:22002721}. Cytoplasm, cytosol {ECO:0000269|PubMed:22002721}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:22002721}; Lipid-anchor {ECO:0000269|PubMed:22002721}; Cytoplasmic side {ECO:0000269|PubMed:22002721}.
Tissue Specificity	Ubiquitous. Highest levels observed in skeletal and cardiac muscle. {ECO:0000269|PubMed:8543055}.
Top Pathways	Insulin signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Choline metabolism in cancer, mTOR signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human GTP-binding protein Rheb Gene - orb91875 from Biorbyt Prices $264.00 Sizes 10 μg Species Human

Human-RHEB-cDNA-Clone - DC08544 from Abgent, a WuXi AppTec company Prices $248.40 Sizes 10 µg Species Human Accession BC066307

RHEB - MBS1266700 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC066307

RHEB - MBS1269054 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC016155

Human RHEB ORF clone(NM_005614.3) - CDCL185978 from Creative Biomart Species Human Accession NM_005614.3

Human RHEB/RHEB2 Gene ORF cDNA clone in cloning vector - HG11382-M from Sino Biological Species Human

Human RHEB/RHEB2 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG11382-CM from Sino Biological Species Human

Human RHEB/RHEB2 Gene ORF cDNA clone expression plasmid, N-HA tag - HG11382-NY from Sino Biological Species Human

Human RHEB/RHEB2 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG11382-ACR from Sino Biological Species Human

Human RHEB/RHEB2 Gene ORF cDNA clone expression plasmid - HG11382-UT from Sino Biological Species Human

Human RHEB/RHEB2 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG11382-M-F from Sino Biological Species Human

Human RHEB Gene cDNA Clone (full-length ORF Clone), expression ready, untagged - HG11382-M-N from Sino Biological Species Human Accession NM_005614.3

Human RHEB/RHEB2 Gene ORF cDNA clone expression plasmid, C-HA tag - HG11382-CY from Sino Biological Species Human

Human RHEB/RHEB2 Gene ORF cDNA clone expression plasmid, C-His tag - HG11382-CH from Sino Biological Species Human

Human RHEB/RHEB2 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG11382-ACG from Sino Biological Species Human

Human RHEB/RHEB2 Gene ORF cDNA clone expression plasmid, N-His tag - HG11382-NH from Sino Biological Species Human

Human RHEB/RHEB2 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG11382-NF from Sino Biological Species Human

Human RHEB/RHEB2 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG11382-NM from Sino Biological Species Human

Human RHEB/RHEB2 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG11382-CF from Sino Biological Species Human

Human RHEB ORF clone(NM_005614.3) - CDCL185978 from Creative biogene Species Human

Human RHEB ORF Clone (BC016155) - CDCS412342 from Creative biogene Species Human Accession Q15382

Human RHEB ORF Clone (BC066307) - CDCS412343 from Creative biogene Species Human Accession Q15382

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