HNRNPK

Gene Symbol	HNRNPK
Entrez Gene	3190
Alt Symbol	CSBP, HNRPK, TUNP
Species	Human
Gene Type	protein-coding
Description	heterogeneous nuclear ribonucleoprotein K
Other Description	dC-stretch binding protein|transformation upregulated nuclear protein
Swissprots	Q59F98 P61978 Q5T6W4
Accessions	EAW62675 EAW62676 EAW62677 EAW62678 EAW62679 EAW62680 EAW62681 P61978 AB209562 BAD92799 AB451263 BAG70077 AB451390 BAG70204 AK096385 BAG53278 AK123117 BAG53872 AK291336 BAF84025 AK294067 BAG57412 AK300744 BAG62413 AK307962 AY911506 AAW84289 BC000355 AAH00355 BC013220 BC014980 AAH14980 BC025321 BU736090 CR456771 CAG33052 DA394419 DC407458 DQ890727 ABM81653 DQ893902 ABM84828 S74678 AAB20770 X72727 CAA51267 XM_005251960 XP_005252017 XM_005251961 XP_005252018 XM_005251963 XP_005252020 XM_005251964 XP_005252021 XM_005251965 XP_005252022 XM_005251966 XP_005252023 XM_011518616 XP_011516918 NM_002140 NP_002131 NM_031262 NP_112552 NM_031263 NP_112553
Function	One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single- stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. {ECO:0000250, ECO:0000269|PubMed:16360036, ECO:0000269|PubMed:20673990, ECO:0000269|PubMed:22825850}.
Subcellular Location	Cytoplasm. Nucleus, nucleoplasm. Cell projection, podosome. Note=Recruited to p53/TP53-responsive promoters, in the presence of functional p53/TP53. In case of ASFV infection, there is a shift in the localization which becomes predominantly nuclear.
Top Pathways	Spliceosome, Herpes simplex infection, Viral carcinogenesis, MicroRNAs in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse/Human/Rat HNRNPK / hnRNP K ELISA Kit (Cell-Based ELISA) - LS-F2056 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 0.313-20 ng/ml

Mouse/Human/Rat Phospho-HNRNPK / hnRNP K (Ser284) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1390 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 0.313-20 ng/ml

Human HNRNPK / hnRNP K ELISA Kit (Sandwich ELISA) - LS-F7932 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.122 ng/ml Range 0.313-20 ng/ml

Human HNRNPK / hnRNP K ELISA Kit (Sandwich ELISA) - LS-F11652 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 78 pg/ml Range 0.313-20 ng/ml

Human HNRPK ELISA Kit - abx151833 from Abbexa Category ELISA Kit Sensitivity 0.107 ng/ml Range 0.313 ng/ml - 20 ng/ml

Heterogeneous nuclear ribonucleoprotein K (HNRNPK), Human, ELISA Kit - E01H0384 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t Sensitivity 1.0ng/ml Range 2.5-50ng/ml

Heterogeneous nuclear ribonucleoprotein K, HNRNPK, Human, ELISA Kit - E0351h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 39-2500 pg/mL

hnRNP K Colorimetric Cell-Based ELISA Kit - CB5339 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

hnRNP K (Phospho-Ser284) Colorimetric Cell-Based ELISA Kit - CBP1410 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

heterogeneous nuclear ribonucleoprotein K, ELISA Kit - MBS706055 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human hnRNP K is typically less than 0.39 ng/ml.The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 1.56 ng/ml -100 ng/ml.

Heterogeneous Nuclear Ribonucleoprotein K, ELISA Kit - MBS057362 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Heterogeneous Nuclear Ribonucleoprotein K, ELISA Kit - MBS079161 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Heterogeneous Nuclear Ribonucleoprotein K, ELISA Kit - MBS104517 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Heterogeneous Nuclear Ribonucleoprotein K, ELISA Kit - MBS095850 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Heterogeneous Nuclear Ribonucleoprotein K, ELISA Kit - MBS099194 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Heterogeneous Nuclear Ribonucleoprotein K, ELISA Kit - MBS083851 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Heterogeneous Nuclear Ribonucleoprotein K, ELISA Kit - MBS099259 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Heterogeneous nuclear ribonucleoprotein K (HNRNPK), ELISA Kit - MBS7223066 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Heterogeneous nuclear ribonucleoprotein K (HNRNPK), ELISA Kit - MBS7250986 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Heterogeneous nuclear ribonucleoprotein K (HNRNPK), ELISA Kit - MBS7211063 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Heterogeneous nuclear ribonucleoprotein K (HNRNPK), ELISA Kit - MBS7248000 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Heterogeneous nuclear ribonucleoprotein K (HNRNPK), ELISA Kit - MBS7249319 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Heterogeneous nuclear ribonucleoprotein K (HNRNPK), ELISA Kit - MBS7232426 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Heterogeneous nuclear ribonucleoprotein K (HNRNPK), ELISA Kit - MBS7242167 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Heterogeneous nuclear ribonucleoprotein K (HNRNPK), ELISA Kit - MBS7242947 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

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