Gene Symbol | HNRNPK |
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Entrez Gene | 3190 |
Alt Symbol | CSBP, HNRPK, TUNP |
Species | Human |
Gene Type | protein-coding |
Description | heterogeneous nuclear ribonucleoprotein K |
Other Description | dC-stretch binding protein|transformation upregulated nuclear protein |
Swissprots | Q59F98 P61978 Q5T6W4 |
Accessions | EAW62675 EAW62676 EAW62677 EAW62678 EAW62679 EAW62680 EAW62681 P61978 AB209562 BAD92799 AB451263 BAG70077 AB451390 BAG70204 AK096385 BAG53278 AK123117 BAG53872 AK291336 BAF84025 AK294067 BAG57412 AK300744 BAG62413 AK307962 AY911506 AAW84289 BC000355 AAH00355 BC013220 BC014980 AAH14980 BC025321 BU736090 CR456771 CAG33052 DA394419 DC407458 DQ890727 ABM81653 DQ893902 ABM84828 S74678 AAB20770 X72727 CAA51267 XM_005251960 XP_005252017 XM_005251961 XP_005252018 XM_005251963 XP_005252020 XM_005251964 XP_005252021 XM_005251965 XP_005252022 XM_005251966 XP_005252023 XM_011518616 XP_011516918 NM_002140 NP_002131 NM_031262 NP_112552 NM_031263 NP_112553 |
Function | One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single- stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. {ECO:0000250, ECO:0000269|PubMed:16360036, ECO:0000269|PubMed:20673990, ECO:0000269|PubMed:22825850}. |
Subcellular Location | Cytoplasm. Nucleus, nucleoplasm. Cell projection, podosome. Note=Recruited to p53/TP53-responsive promoters, in the presence of functional p53/TP53. In case of ASFV infection, there is a shift in the localization which becomes predominantly nuclear. |
Top Pathways | Spliceosome, Herpes simplex infection, Viral carcinogenesis, MicroRNAs in cancer |
hnRNP K CRISPR/Cas9 KO Plasmid (h) - sc-417266 from Santa Cruz Biotechnology
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hnRNP K HDR Plasmid (h) - sc-417266-HDR from Santa Cruz Biotechnology
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hnRNP K Double Nickase Plasmid (h) - sc-417266-NIC from Santa Cruz Biotechnology
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hnRNP K Double Nickase Plasmid (h2) - sc-417266-NIC-2 from Santa Cruz Biotechnology
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hnRNP K CRISPR Activation Plasmid (h) - sc-417266-ACT from Santa Cruz Biotechnology
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hnRNP K CRISPR Activation Plasmid (h2) - sc-417266-ACT-2 from Santa Cruz Biotechnology
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hnRNP K Lentiviral Activation Particles (h) - sc-417266-LAC from Santa Cruz Biotechnology
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hnRNP K Lentiviral Activation Particles (h2) - sc-417266-LAC-2 from Santa Cruz Biotechnology
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hnRNP K siRNA (h) - sc-38282 from Santa Cruz Biotechnology
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hnRNP K shRNA Plasmid (h) - sc-38282-SH from Santa Cruz Biotechnology
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hnRNP K shRNA (h) Lentiviral Particles - sc-38282-V from Santa Cruz Biotechnology
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hnRNP K RNAi - H00003190-R03 from Novus Biologicals
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hnRNP K RNAi - H00003190-R02 from Novus Biologicals
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MISSION® esiRNA - EHU065671 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10207 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10207 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08592 from Sigma-Aldrich
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HNRNPK siRNA (Human) - CRH2180 from Cohesion Biosciences
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hnRNP K RNAi - H00003190-R01 from Novus Biologicals
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HNRNPK - MBS8215619 from MyBioSource
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hnRNP K CRISPR/Cas9 KO Plasmid (h2) - sc-417266-KO-2 from Santa Cruz Biotechnology
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hnRNP K HDR Plasmid (h2) - sc-417266-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human HNRNPK (NM_002140.3) - SHH313817 from Creative biogene
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Human HNRNPK siRNA - orb262682 from Biorbyt
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HNRNPK shRNA Plasmid (Human) - CHH2180 from Cohesion Biosciences
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