HNRNPK

Gene Symbol	HNRNPK
Entrez Gene	3190
Alt Symbol	CSBP, HNRPK, TUNP
Species	Human
Gene Type	protein-coding
Description	heterogeneous nuclear ribonucleoprotein K
Other Description	dC-stretch binding protein|transformation upregulated nuclear protein
Swissprots	Q59F98 P61978 Q5T6W4
Accessions	EAW62675 EAW62676 EAW62677 EAW62678 EAW62679 EAW62680 EAW62681 P61978 AB209562 BAD92799 AB451263 BAG70077 AB451390 BAG70204 AK096385 BAG53278 AK123117 BAG53872 AK291336 BAF84025 AK294067 BAG57412 AK300744 BAG62413 AK307962 AY911506 AAW84289 BC000355 AAH00355 BC013220 BC014980 AAH14980 BC025321 BU736090 CR456771 CAG33052 DA394419 DC407458 DQ890727 ABM81653 DQ893902 ABM84828 S74678 AAB20770 X72727 CAA51267 XM_005251960 XP_005252017 XM_005251961 XP_005252018 XM_005251963 XP_005252020 XM_005251964 XP_005252021 XM_005251965 XP_005252022 XM_005251966 XP_005252023 XM_011518616 XP_011516918 NM_002140 NP_002131 NM_031262 NP_112552 NM_031263 NP_112553
Function	One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single- stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. {ECO:0000250, ECO:0000269|PubMed:16360036, ECO:0000269|PubMed:20673990, ECO:0000269|PubMed:22825850}.
Subcellular Location	Cytoplasm. Nucleus, nucleoplasm. Cell projection, podosome. Note=Recruited to p53/TP53-responsive promoters, in the presence of functional p53/TP53. In case of ASFV infection, there is a shift in the localization which becomes predominantly nuclear.
Top Pathways	Spliceosome, Herpes simplex infection, Viral carcinogenesis, MicroRNAs in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

HNRNPK-Over-expression-Lysate - LY10922a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

HNRNPK overexpression lysate - LY410602 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

HNRNPK overexpression lysate - LY429776 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

HNRNPK 293 Cell Lysate - 400748 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

HNRNPK 293 Cell Lysate - 405405 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

hnRNP K Overexpression Lysate (Native) - NBL1-11645 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

hnRNP K Overexpression Lysate (Native) - NBP2-06147 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

hnRNP K Overexpression Lysate (Native) - NBL1-11647 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

hnRNP K (h2): 293T Lysate - sc-170972 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

HNRNPK Over-expression Lysate Product - GWB-B30CF0 from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

HNRNPK Over-expression Lysate Product - GWB-656A58 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

hnRNP K Overexpression Lysate (Denatured) - H00003190-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Panoply™ Human HNRNPK Knockdown Stable Cell Line - CSC-DC007162 from Creative biogene Category Cell Line Species Human

Search more