HNRNPK

Gene Symbol	HNRNPK
Entrez Gene	3190
Alt Symbol	CSBP, HNRPK, TUNP
Species	Human
Gene Type	protein-coding
Description	heterogeneous nuclear ribonucleoprotein K
Other Description	dC-stretch binding protein|transformation upregulated nuclear protein
Swissprots	Q59F98 P61978 Q5T6W4
Accessions	EAW62675 EAW62676 EAW62677 EAW62678 EAW62679 EAW62680 EAW62681 P61978 AB209562 BAD92799 AB451263 BAG70077 AB451390 BAG70204 AK096385 BAG53278 AK123117 BAG53872 AK291336 BAF84025 AK294067 BAG57412 AK300744 BAG62413 AK307962 AY911506 AAW84289 BC000355 AAH00355 BC013220 BC014980 AAH14980 BC025321 BU736090 CR456771 CAG33052 DA394419 DC407458 DQ890727 ABM81653 DQ893902 ABM84828 S74678 AAB20770 X72727 CAA51267 XM_005251960 XP_005252017 XM_005251961 XP_005252018 XM_005251963 XP_005252020 XM_005251964 XP_005252021 XM_005251965 XP_005252022 XM_005251966 XP_005252023 XM_011518616 XP_011516918 NM_002140 NP_002131 NM_031262 NP_112552 NM_031263 NP_112553
Function	One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single- stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. {ECO:0000250, ECO:0000269|PubMed:16360036, ECO:0000269|PubMed:20673990, ECO:0000269|PubMed:22825850}.
Subcellular Location	Cytoplasm. Nucleus, nucleoplasm. Cell projection, podosome. Note=Recruited to p53/TP53-responsive promoters, in the presence of functional p53/TP53. In case of ASFV infection, there is a shift in the localization which becomes predominantly nuclear.
Top Pathways	Spliceosome, Herpes simplex infection, Viral carcinogenesis, MicroRNAs in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

hnRNP K protein fragment - ab91867 from Abcam Category Protein Prices $119.00 Sizes 20 µg Source E. coli

Human hnRNP K full length protein - ab132460 from Abcam Category Protein Source Wheat germ Species Human

Human hnRNP K peptide - ab19120 from Abcam Category Peptide

Human hnRNP K peptide - ab32584 from Abcam Category Peptide

Human hnRNP K protein fragment - ab167846 from Abcam Category Protein Source E. coli Species Human

HNRNPK / hnRNP K Antibody Blocking Peptide - LS-E14721 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HNRNPK / hnRNP K Antibody Blocking Peptide - LS-E14722 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HNRNPK / hnRNP K Antibody Blocking Peptide - LS-E7154 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

hnRNP K Recombinant Protein - H00003190-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human hnRNP K Protein - NBP2-23120 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

HNRPK-Antibody-N-term-Blocking-Peptide - BP2857a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human HNRPK protein - orb245136 from Biorbyt Category Protein Prices $315.00, $502.00, $782.00, $1,139.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

HNRPK Blocking Peptide - 33R-10254 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

HNRPK Blocking Peptide - 33R-6896 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

hnRNP-K / HNRNPK (1-276, His-tag) - AR51014PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

hnRNP-K / HNRNPK (1-276, His-tag) - AR51014PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

hnRNP-K / HNRNPK - H00003190-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

hnRNP-K / HNRNPK - H00003190-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

HNRNPK, 1-276aa, Human, His tag, E.coli - 01-P2190 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

HNRNPK fusion protein - ag1976 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human heterogeneous nuclear ribonucleoprotein K, His-tagged - HNRNPK-236H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Heterogeneous Nuclear Ribonucleoprotein K (HNRPK) - RPF124Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

hnRNP K (pS284) Blocking Peptide - CBP1538 from Cohesion Biosciences Category Peptide Prices $150.00, $450.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Bovine, Chicken, Rabbit, Zebrafish

hnRNP K (Y280) Peptide - BS2997P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

p-hnRNP K (S284) Peptide - BS4694P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

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