HNRNPK

Gene Symbol HNRNPK
Entrez Gene 3190
Alt Symbol CSBP, HNRPK, TUNP
Species Human
Gene Type protein-coding
Description heterogeneous nuclear ribonucleoprotein K
Other Description dC-stretch binding protein|transformation upregulated nuclear protein
Swissprots Q59F98 P61978 Q5T6W4
Accessions EAW62675 EAW62676 EAW62677 EAW62678 EAW62679 EAW62680 EAW62681 P61978 AB209562 BAD92799 AB451263 BAG70077 AB451390 BAG70204 AK096385 BAG53278 AK123117 BAG53872 AK291336 BAF84025 AK294067 BAG57412 AK300744 BAG62413 AK307962 AY911506 AAW84289 BC000355 AAH00355 BC013220 BC014980 AAH14980 BC025321 BU736090 CR456771 CAG33052 DA394419 DC407458 DQ890727 ABM81653 DQ893902 ABM84828 S74678 AAB20770 X72727 CAA51267 XM_005251960 XP_005252017 XM_005251961 XP_005252018 XM_005251963 XP_005252020 XM_005251964 XP_005252021 XM_005251965 XP_005252022 XM_005251966 XP_005252023 XM_011518616 XP_011516918 NM_002140 NP_002131 NM_031262 NP_112552 NM_031263 NP_112553
Function One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single- stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. {ECO:0000250, ECO:0000269|PubMed:16360036, ECO:0000269|PubMed:20673990, ECO:0000269|PubMed:22825850}.
Subcellular Location Cytoplasm. Nucleus, nucleoplasm. Cell projection, podosome. Note=Recruited to p53/TP53-responsive promoters, in the presence of functional p53/TP53. In case of ASFV infection, there is a shift in the localization which becomes predominantly nuclear.
Top Pathways Spliceosome, Herpes simplex infection, Viral carcinogenesis, MicroRNAs in cancer

hnRNP K (D9A8) Rabbit mAb - 9081 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D9A8
Western blot analysis of extracts from various cell lines using hnRNP K (D9A8) Rabbit mAb.

hnRNP K (A222) Antibody - 4699 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa and Hep G2 cells using hnRNP K (A222) Antibody.

hnRNP K (R332) Antibody - 4675 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa and Hep G2 cells using hnRNP K (R332) Antibody.

hnRNP K (D-6) - sc-28380 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
hnRNP K (D-6): sc-28380. Immunoperoxidase staining of formalin fixed, paraffin-embedded human esophagus tissue showing nuclear and cytoplasmic staining of surface epithelial cells at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

hnRNP K (F45 P9 C7) - sc-53620 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
hnRNP K (F45 P9 C7): sc-53620. Western blot analysis of hnRNP K expression in HeLa (A), KNRK (B), Sol8 (C) and NIH/3T3 (D) nuclear extracts.

hnRNP K (H-300) - sc-25373 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
hnRNP K (H-300): sc-25373. Western blot analysis of hnRNP K expression in HeLa (A), KNRK (B), Sol8 (C) and NIH/3T3 (D) nuclear extracts.

hnRNP K (P-20) - sc-16554 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
hnRNP K (P-20): sc-16554. Western blot analysis of hnRNP K expression in HeLa (A) and KNRK (B) nuclear extracts.

hnRNP K/J (3C2) - sc-32307 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
hnRNP K/J (3C2): sc-32307. Western blot analysis of hnRNP K and hnRNP J expression in Sol8 (A), KNRK (B) and HeLa (C) whole cell lysates.

p-hnRNP K (H-5) - sc-365998 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Western blot analysis of hnRNP K phosphorylation in untreated (A,D), PMA treated (B,E) and PMA and lambda protein phosphatase (sc-200312A) treated (C,F) THP-1 whole cell lysates. Antibodies tested include p-hnRNP K (H-5): sc-365998 (A,B,C) and hnRNP K (H-300): sc-25373 (D,E,F).

p-hnRNP K (Ser 302) - sc-18361 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-hnRNP K (phospho S284) antibody - ab74066 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-hnRNP K (phospho S284) antibody (ab74066) at 1/500 dilutionLane 1 : Extracts from 3T3 cells treated with EGF (200ng/ml, 30mins)Lane 2 : Extracts from 3T3 cells treated with EGF (200ng/ml, 30mins) with immunising phosphopeptide at 10 µgLysates/proteins at 30 µg per lane.

Anti-hnRNP K antibody - ab32969 from Abcam

Prices $390.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC image of hnRNP K staining in Human Colon Adenocarcinoma formalin fixed paraffin embedded tissue section, performed on a Leica Bond™ system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab32969, 1 µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Anti-hnRNP K antibody - ab18195 from Abcam

Prices $390.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
IHC image of hnRNP K staining in Human Colon Adenocarcinoma formalin fixed paraffin embedded tissue section, performed on a Leica Bond™ system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab18195, 0.5 µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Anti-hnRNP K antibody - ab70491 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-hnRNP K antibody (ab70491) at 0.1 µg/mlLane 1 : HeLa whole cell lysate at 50 µgLane 2 : HeLa whole cell lysate at 15 µgLane 3 : HeLa whole cell lysate at 5 µgLane 4 : 293T whole cell lysate at 50 µgLane 5 : NIH3T3 whole cell lysate at 50 µg

Anti-hnRNP K antibody - ab74129 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-hnRNP K antibody (ab74129) at 1/500 dilutionLane 1 : Extracts from LOVO cells with no peptideLane 2 : Extracts from RAW264.7 cells with no peptideLane 3 : Extracts from LOVO cells with peptide at 5 µgLysates/proteins at 5 µg per lane.

Anti-hnRNP K antibody [EP943Y] - ab52600 from Abcam

Prices $390.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP943Y
Anti-hnRNP K antibody [EP943Y] (ab52600) at 1/100000 dilution + Jurkat cell lysate at 10 µgSecondaryHRP-labelled goat anti-rabbit at 1/2000 dilution

Anti-hnRNP K antibody [EPR10933] - ab156570 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR10933
ab156570 showing +ve staining in Human normal tonsil.

Anti-hnRNP K antibody [EPR944] - ab134060 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR944
All lanes : Anti-hnRNP K antibody [EPR944] (ab134060) at 1/50000 dilutionLane 1 : Jurkat cell lysateLane 2 : A549 cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-hnRNP K antibody [F45 P9 C7] - ab23644 from Abcam

Prices $390.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone F45 P9 C7
Lane 1 : MarkerLanes 2 - 5 : Anti-hnRNP K antibody [F45 P9 C7] (ab23644) at 1 µg/mlLane 1 : As aboveLane 2 : HeLa (Human epithelial carcinoma cell line) Nuclear Lysate (ab27251) at 20 µgLane 3 : HeLa (Human epithelial carcinoma cell line) Whole Cell Lysate (ab27252) at 20 µgLane 4 : Jurkat (Human T cell lymphoblast-like cell line) Whole Cell Lysate (ab7899) at 20 µgLane 5 : HEK293 (Human embryonic kidney cell line) Whole Cell Lysate (ab7902) at 20 µgSecondaryLanes 2 - 5 : Rabbit Anti-Mouse IgG H&L (HRP) (ab6728) at 1/10000 dilutionPerformed under reducing conditions.

Anti-hnRNP K antibody [F45 P9 C7] (FITC) - ab150277 from Abcam

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone F45 P9 C7

Anti-hnRNP K antibody [F45 P9 C7] - BSA and Azide free - ab174748 from Abcam

Prices $372.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone F45 P9 C7

Anti-HNRNPK / hnRNP K Antibody - LS-C27036 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal
Left and Center: IHC of normal colon (left) and colon carninoma (center) using hnRNP-K antibody (LS-C27036). Right: Western blot of hnRNP-K antibody on Calu6 (1) and HT29 (2) cell lysates.

Anti-HNRNPK / hnRNP K Antibody - LS-C121961 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-HNRNPK / hnRNP K Antibody (aa380-430) IHC-plus™ - LS-B7996 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-HnRNP K antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7996 dilution 5-10 ug/ml.

Anti-HNRNPK / hnRNP K Antibody - LS-C331644 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded rat liver using HNRNPK antibody at dilution of 1:200 (400x lens).
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