SPDYA

Gene Symbol	SPDYA
Entrez Gene	245711
Alt Symbol	RINGO3, RINGOA, SPDY1, SPY1
Species	Human
Gene Type	protein-coding
Description	speedy/RINGO cell cycle regulator family member A
Other Description	RINGO A\|hSpy/Ringo A\|rapid inducer of G2/M progression in oocytes A\|speedy homolog A\|speedy protein A\|speedy-1
Swissprots	Q5MJ69 Q53R05 Q5MJ70
Accessions	AAY24014 AAY24125 EAX00526 Q5MJ70 AA625975 AY820303 AAW30394 AY820304 AAW30395 BC047224 BC093005 AAH93005 NM_001008779 NP_001008779 NM_001142634 NP_001136106 NM_182756 NP_877433
Function	Regulates the G1/S phase transition of the cell cycle by binding and activating CDK1, CDK2 and CDKN1B/KIP1. Can activate CDK2 without promoting CDK2 phosphorylation. Mediates cell survival during the DNA damage process through activation of CDK2. {ECO:0000269\|PubMed:11980914, ECO:0000269\|PubMed:12839962, ECO:0000269\|PubMed:12972555}.
Subcellular Location	Nucleus {ECO:0000269\|PubMed:11980914, ECO:0000269\|PubMed:12972555}.
Tissue Specificity	Highly expressed in testis. Expressed at a low level in wide range of tissues including bone marrow, brain, heart, kidney, colon, liver, placenta, spleen, skeletal muscle, salivary gland, thyroid gland, thymus, trachea and uterus. Expressed at a slightly higher level in adrenal gland, cerebellum, small intestine, lung, prostate and trachea. Expression is cell cycle-dependent, being restricted to cells in G1/S phase. {ECO:0000269\|PubMed:11980914, ECO:0000269\|PubMed:15611625}.
Top Pathways	Progesterone-mediated oocyte maturation, Oocyte meiosis

Speedy A (A-13) - sc-139170 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Speedy A (G-15) - sc-139171 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Anti-SPDYA antibody - ab86168 from Abcam

Prices	$370.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-SPDYA antibody (ab86168) at 1 µg/ml (in 5% skim milk / PBS buffer) + human fetal heart lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-SPY1 / SPDYA Antibody (C-Terminus, Biotin) - LS-C141037 from LifeSpan Bioscience

Prices	$365.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-SPY1 / SPDYA Antibody (C-Terminus, DY650) - LS-C141038 from LifeSpan Bioscience

Prices	$365.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-SPY1 / SPDYA Antibody (C-Terminus, DY488) - LS-C141039 from LifeSpan Bioscience

Prices	$365.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-SPY1 / SPDYA Antibody (C-Terminus, DY550) - LS-C141041 from LifeSpan Bioscience

Prices	$365.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-SPY1 / SPDYA Antibody (C-Terminus, HRP) - LS-C141040 from LifeSpan Bioscience

Prices	$365.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-SPY1 / SPDYA Antibody (N-Terminus) - LS-C102694 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

SPDYA antibody LS-C102694 Western blot of HeLa lysate.

Anti-SPY1 / SPDYA Antibody (aa200-286) - LS-C49019 from LifeSpan Bioscience

Prices	$335.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Detection of Speedy/Ringo in mouse testis using antibody at 2 ug/ml.

Anti-SPY1 / SPDYA Antibody (C-Terminus) - LS-C102695 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

SPDYA antibody LS-C102695 Western blot of Fetal Heart lysate.

Anti-SPY1 / SPDYA Antibody - LS-C331940 from LifeSpan Bioscience

Prices	$255.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Western blot analysis of extracts of various cell lines, using SPDYA antibody.

Anti-SPY1 / SPDYA Antibody - LS-C192979 from LifeSpan Bioscience

Prices	$385.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Western blot of extracts of various cell lines, using SPDYA antibody.

Speedy/Ringo Antibody - NB100-2521 from Novus Biologicals

Prices	$99.00, $299.00
Sizes	25 µl, 100 µl
Host	Rabbit
Clonality	Polyclonal

Speedy/Ringo Antibody - 44250002 from Novus Biologicals

Prices	$299.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Speedy/Ringo Antibody [Alexa Fluor (R) 700] - NB100-2521AF700 from Novus Biologicals

Prices	$319.00
Sizes	100 tests
Host	Rabbit
Clonality	Polyclonal

Speedy/Ringo Antibody [Alexa Fluor (R) 647] - NB100-2521AF647 from Novus Biologicals

Prices	$319.00
Sizes	100 tests
Host	Rabbit
Clonality	Polyclonal

Speedy/Ringo Antibody [Alexa Fluor (R) 488] - NB100-2521AF488 from Novus Biologicals

Prices	$329.00
Sizes	100 tests
Host	Rabbit
Clonality	Polyclonal

Speedy/Ringo Antibody [Alexa Fluor (R) 405] - NB100-2521AF405 from Novus Biologicals

Prices	$319.00
Sizes	100 tests
Host	Rabbit
Clonality	Polyclonal

Speedy/Ringo Antibody [DyLight 488] - NB100-2521G from Novus Biologicals

Prices	$319.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Speedy/Ringo Antibody [Biotin] - NB100-2521B from Novus Biologicals

Prices	$299.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Speedy/Ringo Antibody [DyLight 650] - NB100-2521C from Novus Biologicals

Prices	$319.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Speedy/Ringo Antibody [HRP] - NB100-2521H from Novus Biologicals

Prices	$319.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Speedy/Ringo Antibody [DyLight 550] - NB100-2521R from Novus Biologicals

Prices	$319.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Speedy/Ringo Antibody [FITC] - NB100-2521F from Novus Biologicals

Prices	$309.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

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