| Gene Symbol | SPDYA |
|---|---|
| Entrez Gene | 245711 |
| Alt Symbol | RINGO3, RINGOA, SPDY1, SPY1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | speedy/RINGO cell cycle regulator family member A |
| Other Description | RINGO A|hSpy/Ringo A|rapid inducer of G2/M progression in oocytes A|speedy homolog A|speedy protein A|speedy-1 |
| Swissprots | Q5MJ69 Q53R05 Q5MJ70 |
| Accessions | AAY24014 AAY24125 EAX00526 Q5MJ70 AA625975 AY820303 AAW30394 AY820304 AAW30395 BC047224 BC093005 AAH93005 NM_001008779 NP_001008779 NM_001142634 NP_001136106 NM_182756 NP_877433 |
| Function | Regulates the G1/S phase transition of the cell cycle by binding and activating CDK1, CDK2 and CDKN1B/KIP1. Can activate CDK2 without promoting CDK2 phosphorylation. Mediates cell survival during the DNA damage process through activation of CDK2. {ECO:0000269|PubMed:11980914, ECO:0000269|PubMed:12839962, ECO:0000269|PubMed:12972555}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:11980914, ECO:0000269|PubMed:12972555}. |
| Tissue Specificity | Highly expressed in testis. Expressed at a low level in wide range of tissues including bone marrow, brain, heart, kidney, colon, liver, placenta, spleen, skeletal muscle, salivary gland, thyroid gland, thymus, trachea and uterus. Expressed at a slightly higher level in adrenal gland, cerebellum, small intestine, lung, prostate and trachea. Expression is cell cycle-dependent, being restricted to cells in G1/S phase. {ECO:0000269|PubMed:11980914, ECO:0000269|PubMed:15611625}. |
| Top Pathways | Progesterone-mediated oocyte maturation, Oocyte meiosis |
Human SPDYA cDNA clone(NM_001008779.1) - CDFH018454 from Creative Biomart
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Human SPDYA cDNA clone(NM_001142634.1) - CDFH018455 from Creative Biomart
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Human SPDYA ORF Clone(NM_001008779.1) - CDCR340546 from Creative Biomart
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Human SPDYA ORF Clone(NM_001008779.1) - CDCR340547 from Creative Biomart
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Human SPDYA ORF Clone(NM_001142634.1) - CDCR351539 from Creative Biomart
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Human SPDYA ORF Clone(NM_001142634.1) - CDCR351540 from Creative Biomart
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human SPDYA ORF clone - CDCH085122 from Creative Biomart
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human SPDYA ORF clone - CDCH085123 from Creative Biomart
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human SPDYA ORF clone - CDCH085124 from Creative Biomart
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human SPDYA ORF clone - CDCH085125 from Creative Biomart
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human SPDYA ORF clone - CDCH085126 from Creative Biomart
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human SPDYA ORF clone - CDCH085127 from Creative Biomart
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Human SPDYA ORF clone(NM_182756.3) - CDCH402106 from Creative Biomart
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Human SPDYA ORF Clone(NM_001008779.1) - CDCL176814 from Creative Biomart
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Human SPDYA ORF Clone(NM_001008779.1) - CDCL176815 from Creative Biomart
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Human SPDYA ORF clone(NM_182756.3) - CDCH402106 from Creative biogene
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Human SPDYA ORF Clone(NM_001142634.1) - CDCR351539 from Creative biogene
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human SPDYA ORF clone (NM_001008779.1) - CDCH085122 from Creative biogene
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Human SPDYA cDNA Clone(NM_001008779.1) - CDFH018454 from Creative biogene
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Human SPDYA cDNA Clone(NM_001142634.1) - CDFH018455 from Creative biogene
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