| Gene Symbol | SPDYA |
|---|---|
| Entrez Gene | 245711 |
| Alt Symbol | RINGO3, RINGOA, SPDY1, SPY1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | speedy/RINGO cell cycle regulator family member A |
| Other Description | RINGO A|hSpy/Ringo A|rapid inducer of G2/M progression in oocytes A|speedy homolog A|speedy protein A|speedy-1 |
| Swissprots | Q5MJ69 Q53R05 Q5MJ70 |
| Accessions | AAY24014 AAY24125 EAX00526 Q5MJ70 AA625975 AY820303 AAW30394 AY820304 AAW30395 BC047224 BC093005 AAH93005 NM_001008779 NP_001008779 NM_001142634 NP_001136106 NM_182756 NP_877433 |
| Function | Regulates the G1/S phase transition of the cell cycle by binding and activating CDK1, CDK2 and CDKN1B/KIP1. Can activate CDK2 without promoting CDK2 phosphorylation. Mediates cell survival during the DNA damage process through activation of CDK2. {ECO:0000269|PubMed:11980914, ECO:0000269|PubMed:12839962, ECO:0000269|PubMed:12972555}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:11980914, ECO:0000269|PubMed:12972555}. |
| Tissue Specificity | Highly expressed in testis. Expressed at a low level in wide range of tissues including bone marrow, brain, heart, kidney, colon, liver, placenta, spleen, skeletal muscle, salivary gland, thyroid gland, thymus, trachea and uterus. Expressed at a slightly higher level in adrenal gland, cerebellum, small intestine, lung, prostate and trachea. Expression is cell cycle-dependent, being restricted to cells in G1/S phase. {ECO:0000269|PubMed:11980914, ECO:0000269|PubMed:15611625}. |
| Top Pathways | Progesterone-mediated oocyte maturation, Oocyte meiosis |
Speedy A CRISPR/Cas9 KO Plasmid (h) - sc-417387 from Santa Cruz Biotechnology
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Speedy A HDR Plasmid (h) - sc-417387-HDR from Santa Cruz Biotechnology
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Speedy A Double Nickase Plasmid (h) - sc-417387-NIC from Santa Cruz Biotechnology
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Speedy A Double Nickase Plasmid (h2) - sc-417387-NIC-2 from Santa Cruz Biotechnology
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Speedy A CRISPR Activation Plasmid (h) - sc-417387-ACT from Santa Cruz Biotechnology
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Speedy A CRISPR Activation Plasmid (h2) - sc-417387-ACT-2 from Santa Cruz Biotechnology
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Speedy A Lentiviral Activation Particles (h) - sc-417387-LAC from Santa Cruz Biotechnology
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Speedy A Lentiviral Activation Particles (h2) - sc-417387-LAC-2 from Santa Cruz Biotechnology
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Speedy A siRNA (h) - sc-94630 from Santa Cruz Biotechnology
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Speedy A shRNA Plasmid (h) - sc-94630-SH from Santa Cruz Biotechnology
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Speedy A shRNA (h) Lentiviral Particles - sc-94630-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN20441 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20441 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05701 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03678 from Sigma-Aldrich
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SPDYA siRNA (Human) - CRJ6592 from Cohesion Biosciences
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SPDYA - MBS8229872 from MyBioSource
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shRNA set against Human SPDYA (NM_182756.3) - SHH416364 from Creative biogene
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shRNA set against Human SPDYA(NM_001008779.1) - SHL027542 from Creative biogene
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SPDYA shRNA Plasmid (Human) - CHJ6592 from Cohesion Biosciences
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SPDYA miRNA 3'UTR clone - MiUTR1H-09828 from Creative biogene
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SPDYA miRNA 3'UTR clone - MiUTR3H-13107 from Creative biogene
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SPDYA miRNA 3'UTR clone - MiUTR3H-13108 from Creative biogene
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