| Gene Symbol |
SPDYA
|
| Entrez Gene |
245711
|
| Alt Symbol |
RINGO3, RINGOA, SPDY1, SPY1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
speedy/RINGO cell cycle regulator family member A
|
| Other Description |
RINGO A|hSpy/Ringo A|rapid inducer of G2/M progression in oocytes A|speedy homolog A|speedy protein A|speedy-1
|
| Swissprots |
Q5MJ69 Q53R05 Q5MJ70
|
| Accessions |
AAY24014 AAY24125 EAX00526 Q5MJ70 AA625975 AY820303 AAW30394 AY820304 AAW30395 BC047224 BC093005 AAH93005 NM_001008779 NP_001008779 NM_001142634 NP_001136106 NM_182756 NP_877433
|
| Function |
Regulates the G1/S phase transition of the cell cycle by binding and activating CDK1, CDK2 and CDKN1B/KIP1. Can activate CDK2 without promoting CDK2 phosphorylation. Mediates cell survival during the DNA damage process through activation of CDK2. {ECO:0000269|PubMed:11980914, ECO:0000269|PubMed:12839962, ECO:0000269|PubMed:12972555}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:11980914, ECO:0000269|PubMed:12972555}.
|
| Tissue Specificity |
Highly expressed in testis. Expressed at a low level in wide range of tissues including bone marrow, brain, heart, kidney, colon, liver, placenta, spleen, skeletal muscle, salivary gland, thyroid gland, thymus, trachea and uterus. Expressed at a slightly higher level in adrenal gland, cerebellum, small intestine, lung, prostate and trachea. Expression is cell cycle-dependent, being restricted to cells in G1/S phase. {ECO:0000269|PubMed:11980914, ECO:0000269|PubMed:15611625}.
|
| Top Pathways |
Progesterone-mediated oocyte maturation, Oocyte meiosis
|