SPDYA

Gene Symbol	SPDYA
Entrez Gene	245711
Alt Symbol	RINGO3, RINGOA, SPDY1, SPY1
Species	Human
Gene Type	protein-coding
Description	speedy/RINGO cell cycle regulator family member A
Other Description	RINGO A|hSpy/Ringo A|rapid inducer of G2/M progression in oocytes A|speedy homolog A|speedy protein A|speedy-1
Swissprots	Q5MJ69 Q53R05 Q5MJ70
Accessions	AAY24014 AAY24125 EAX00526 Q5MJ70 AA625975 AY820303 AAW30394 AY820304 AAW30395 BC047224 BC093005 AAH93005 NM_001008779 NP_001008779 NM_001142634 NP_001136106 NM_182756 NP_877433
Function	Regulates the G1/S phase transition of the cell cycle by binding and activating CDK1, CDK2 and CDKN1B/KIP1. Can activate CDK2 without promoting CDK2 phosphorylation. Mediates cell survival during the DNA damage process through activation of CDK2. {ECO:0000269|PubMed:11980914, ECO:0000269|PubMed:12839962, ECO:0000269|PubMed:12972555}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:11980914, ECO:0000269|PubMed:12972555}.
Tissue Specificity	Highly expressed in testis. Expressed at a low level in wide range of tissues including bone marrow, brain, heart, kidney, colon, liver, placenta, spleen, skeletal muscle, salivary gland, thyroid gland, thymus, trachea and uterus. Expressed at a slightly higher level in adrenal gland, cerebellum, small intestine, lung, prostate and trachea. Expression is cell cycle-dependent, being restricted to cells in G1/S phase. {ECO:0000269|PubMed:11980914, ECO:0000269|PubMed:15611625}.
Top Pathways	Progesterone-mediated oocyte maturation, Oocyte meiosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SPDYA full length protein - ab166002 from Abcam Category Protein Source Wheat germ Species Human

SPY1 / SPDYA Antibody Blocking Peptide - LS-E20208 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SPY1 / SPDYA Antibody Blocking Peptide - LS-E20207 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Speedy/Ringo Blocking Peptide - NB100-2521PEP from Novus Biologicals Category Peptide Prices $69.00 Sizes 50 µg Species Human

Recombinant Human Speedy/Ringo Protein - H00245711-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

SPDYA-Antibody-Center-Blocking-Peptide - BP9978a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SPDYA Blocking Peptide - 33R-3860 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SPDYA Blocking Peptide - 33R-6362 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Speedy-1 / RINGO A - H00245711-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

Speedy-1 / RINGO A - H00245711-P01-10 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

SPDYA fusion protein - ag12218 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

SPDYA fusion protein - ag12041 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human Speedy protein A(SPDYA) - CSB-YP708792HU CSB-EP708792HU CSB-BP708792HU CSB-MP708792HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Speedy/Ringo Recombinant Protein Antigen - NBP2-49476PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E. coli Species Human

SPDYA Peptide, Human - M34GP15020H from Creative Peptides Category Peptide Source Synthetic. Species Human

Speedy protein A (SPDYA), Recombinant Protein - MBS1297394 from MyBioSource Category Protein Prices $1,070.00, $1,070.00, $1,300.00, $1,300.00, $1,675.00, $1,675.00, $2,140.00, $2,140.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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