SIGLEC12

Gene Symbol	SIGLEC12
Entrez Gene	89858
Alt Symbol	S2V, SIGLECL1, SLG, Siglec-XII
Species	Human
Gene Type	protein-coding
Description	sialic acid binding Ig-like lectin 12 (gene/pseudogene)
Other Description	SIGLEC-like 1\|sialic acid-binding Ig-like lectin 12\|sialic acid-binding Ig-like lectin-like 1
Swissprots	Q8IYH7 Q96PQ1
Accessions	AAK51233 AAK51234 EAW72022 EAW72023 Q96PQ1 AF282256 AAK71521 AI132995 AK095919 BAG53167 AK225931 AY358140 AAQ88507 BC035809 AAH35809 DA562082 XM_011527441 XP_011525743 XM_011527442 XP_011525744 NM_033329 NP_201586 NM_053003 NP_443729
Function	Putative adhesion molecule that mediates sialic-acid dependent binding to cells. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
Subcellular Location	Membrane; Single-pass type I membrane protein.
Tissue Specificity	Isoform Short is highly expressed in spleen, small intestine and adrenal gland; it is lower expressed in thyroid, placenta, brain, stomach, bone marrow, spinal chord and breast. Isoform Long is highly expressed in spleen, small intestine and bone marrow; it is lower expressed in thyroid, placenta, thymus, trachea, stomach, lung, adrenal gland, fetal brain and testis.

Siglec-12 (C-14) - sc-55284 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Siglec-12 (X-23) - sc-130875 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	100 µg/ml
Host	Rabbit
Clonality	Polyclonal

Anti-SIGLECL1 antibody - ab106537 from Abcam

Prices	$370.00
Sizes	50 µl
Host	Rabbit
Clonality	Polyclonal

Anti-SIGLECL1 antibody (ab106537) at 1/2000 dilution + MCF7 whole cell lysate at 30 µg

Anti-SIGLECL1 antibody - ab14752 from Abcam

Prices	$242.00
Sizes	100 µg
Host	Goat
Clonality	Polyclonal

Anti-SIGLECL1 antibody - C-terminal - ab172940 from Abcam

Prices	$370.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

Immunohistochemical analysis of formalin-fixed paraffin-embedded Human spleen tissue, labeling SIGLECL1 using ab172940 at a 1/50 dilution, followed by peroxidase conjugation of the secondary antibody and DAB staining.

Anti-SIGLEC12 Antibody (aa464-477) - LS-C55466 from LifeSpan Bioscience

Prices	$335.00
Sizes	100 µg
Host	Goat
Clonality	Polyclonal

Anti-SIGLEC12 Antibody (aa22-218, Biotin) - LS-C299223 from LifeSpan Bioscience

Prices	$435.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-SIGLEC12 Antibody (aa27-141, Biotin) - LS-C301161 from LifeSpan Bioscience

Prices	$435.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-SIGLEC12 Antibody (aa27-141, FITC) - LS-C303325 from LifeSpan Bioscience

Prices	$445.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-SIGLEC12 Antibody (aa22-218, FITC) - LS-C304777 from LifeSpan Bioscience

Prices	$435.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-SIGLEC12 Antibody (aa218-267) - LS-C81530 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

HepG2 cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-SIGLEC12 Antibody (aa27-141) - LS-C296406 from LifeSpan Bioscience

Prices	$395.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Western blot of recombinant SIGLEC12 / SIGLEC-12.

Anti-SIGLEC12 Antibody (aa22-218) - LS-C296408 from LifeSpan Bioscience

Prices	$395.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-SIGLEC12 Antibody (aa38-87) - LS-C81538 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Jurkat cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-SIGLEC12 Antibody (aa565-595) - LS-C161089 from LifeSpan Bioscience

Prices	$295.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

Formalin-fixed and paraffin-embedded human spleen tissue reacted with SIGLEC12 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Anti-SIGLEC12 Antibody (aa110-159) - LS-C81539 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

SIGLECL1 Antibody - NBP2-14794 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Western Blot: SIGLEC1 Antibody [NBP2-14794] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10<br/>Lane 2: Negative control (vector only transfected HEK293T lysate)<br/>Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells, LY406523)

SIGLECL12 Antibody - NBP2-20362 from Novus Biologicals

Prices	$329.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Western Blot: SIGLECL1 Antibody [NBP2-20362] - Sample (30 ug of whole cell lysate) A: MCF-7 7. 5% SDS PAGE gel, diluted at 1:2000.

SIGLECL1 Antibody - NBP2-14393 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunohistochemistry-Paraffin: SIGLEC1 Antibody [NBP2-14393] - SIGLEC1 Antibody Staining of human pancreas shows strong cytoplasmic positivity(granular pattern) in exocrine glandular cells and islets of Langerhans.

SIGLECL12 Antibody - NBP1-59243 from Novus Biologicals

Prices	$139.00, $329.00
Sizes	20 µl, 100 µl
Host	Rabbit
Clonality	Polyclonal

SIGLECL12 Antibody - NBP1-59241 from Novus Biologicals

Prices	$139.00, $329.00
Sizes	20 µl, 100 µl
Host	Rabbit
Clonality	Polyclonal

Western Blot: SIGLECL1 Antibody [NBP1-59241] - HepG2 cell lysate, concentration 0.2-1 ug/ml.

SIGLECL12 Antibody - H00089858-B01 from Novus Biologicals

Prices	$349.00
Sizes	50 µl
Host	Mouse
Clonality	Polyclonal

Western Blot: SIGLECL12 Antibody [H00089858-B01] - analysis of SIGLEC12 expression in transfected 293T cell line by SIGLEC12 MaxPab polyclonal antibody (B01). Lane 1: SIGLEC12 transfected lysate (65.00 KDa). Lane 2: Non-transfected lysate.

SIGLECL12 Antibody - NB100-1174 from Novus Biologicals

Prices	$229.00
Sizes	100 µg
Host	Goat
Clonality	Polyclonal

Anti-Siglec-12 (AB2) antibody produced in rabbit - AV50235 from Sigma-Aldrich

Prices	$347.50
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

<B>Immunoblotting</B><BR/>Cell Type: Jurkat (<B>Cat. No. AV50235</B>).<BR/><B>Lanes</B><BR/>1. Antibody dilution (concentration) 1 μg/mL in cell type Jurkat

Anti-Siglec-12 (AB1) antibody produced in rabbit - AV50183 from Sigma-Aldrich

Prices	$347.50
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

<B>Immunoblotting</B><BR/>Cell Type: HepG2 (<B>Cat. No. AV50183</B>).<BR/><B>Lanes</B><BR/>1. Antibody dilution (concentration) 1 μg/mL in cell type HepG2

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