TRIM63

Gene Symbol	TRIM63
Entrez Gene	84676
Alt Symbol	IRF, MURF1, MURF2, RNF28, SMRZ
Species	Human
Gene Type	protein-coding
Description	tripartite motif containing 63, E3 ubiquitin protein ligase
Other Description	E3 ubiquitin-protein ligase TRIM63|iris ring finger protein|muscle specific ring finger protein 2|muscle-specific RING finger protein 1|ring finger protein 28|striated muscle RING zinc finger protein|tripartite motif-containing protein 63
Swissprots	Q9BYV4 B4DN95 Q96KD9 Q5T2I1 Q969Q1 Q96BD3
Accessions	EAX07848 Q969Q1 AF353673 AAK39519 AF361946 AAK52497 AI351421 AJ276484 CAC81706 AK056942 BAB71318 AK297820 BAG60157 BC080529 AAH80529 BT007373 AAP36037 DA900348 NM_032588 NP_115977
Function	E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti- hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells. {ECO:0000269|PubMed:11927605, ECO:0000269|PubMed:18222470}.
Subcellular Location	Cytoplasm. Nucleus {ECO:0000250}. Cytoplasm, myofibril, sarcomere, M line. Cytoplasm, myofibril, sarcomere, Z line. Note=Colocalizes with TNNI3 in myocytes (By similarity). Localizes to the M- and Z-lines in skeletal muscle. {ECO:0000250}.
Tissue Specificity	Muscle specific. Selectively expressed in heart and skeletal muscle. Also expressed in the iris. {ECO:0000269|PubMed:11243782, ECO:0000269|PubMed:11283016, ECO:0000269|PubMed:11679633, ECO:0000269|PubMed:12107412}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human MuRF1/TRIM63 Ubiquitin Ligase Kit - S5a Substrate - K-102 from R&D Systems Prices $395.00 Sizes 1 kit

E3 ubiquitin-protein ligase TRIM63 (TRIM63), Human, ELISA Kit - CSB-EL024502HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 3.1 pg/ml Range 12.5 pg/ml-800 pg/ml

TRIM63 (Human) IP-WB Antibody Pair - H00084676-PW2 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

TRIM63 (Human) Matched Antibody Pair - H00084676-AP61 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

Mumps IgM , ELISA Kit - MBS580116 from MyBioSource Category ELISA Kit Prices $295.00 Sizes 96 -strip-wells

tripartite motif-containing 63, ELISA Kit - MBS947128 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human TRIM63 is typically less than 3.1 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 12.5 pg/ml -800 pg/ml.

Human E3 ubiquitin-protein ligase TRIM63(TRIM63) ELISA kit - CSB-EL024502HU from Cusabio Category ELISA Kit Sensitivity 3.1 pg/ml Range 12.5 pg/ml-800 pg/ml

MuRF1/TRIM63 Ubiquitin Ligase Kit - S5a Substrate - K-102 from Boston Biochem Prices $395.00 Sizes 1 kit

Mouse MURF1 / IRF ELISA Kit (Sandwich ELISA) - LS-F23539 from LifeSpan Bioscience Category ELISA Kit Prices $590.00 Sizes 1 plate Sensitivity 18.75 pg/ml Range 31.25-2000 pg/ml

Human IRF ELISA Kit - E020320 from Biobool Category ELISA Kit

Human MuRF1 ELISA Kit - E025185 from Biobool Category ELISA Kit

Human TRIM63 ELISA Kit - E039510 from Biobool Category ELISA Kit Sensitivity The minimum detectable dose of human TRIM63 is typically less than 3.1 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the me

TRIM63 ELISA Kit (Human) (OKCA00667) - OKCA00667 from Aviva Systems Biology Category ELISA Kit Prices $590.00 Sizes 96 wells Sensitivity 3.1 pg/mL Range 12.5 pg/mL-800 pg/mL

anti-MURF1 / TRIM63 antibody - ARG63271 from Arigo Biolaboratories Category ELISA Kit

Mouse MURF1 / IRF ELISA Kit (Sandwich ELISA) - LS-F36412 from LifeSpan Bioscience Category ELISA Kit Sensitivity 18.75 Range 31.25-2000 pg/ml

Human TRIM63 ELISA Kit - orb405718 from Biorbyt Category ELISA Kit Sensitivity 3.1 pg/ml Range 12.5 pg/ml-800 pg/ml

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