| Gene Symbol |
TRIM63
|
| Entrez Gene |
84676
|
| Alt Symbol |
IRF, MURF1, MURF2, RNF28, SMRZ
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
tripartite motif containing 63, E3 ubiquitin protein ligase
|
| Other Description |
E3 ubiquitin-protein ligase TRIM63|iris ring finger protein|muscle specific ring finger protein 2|muscle-specific RING finger protein 1|ring finger protein 28|striated muscle RING zinc finger protein|tripartite motif-containing protein 63
|
| Swissprots |
Q9BYV4 B4DN95 Q96KD9 Q5T2I1 Q969Q1 Q96BD3
|
| Accessions |
EAX07848 Q969Q1 AF353673 AAK39519 AF361946 AAK52497 AI351421 AJ276484 CAC81706 AK056942 BAB71318 AK297820 BAG60157 BC080529 AAH80529 BT007373 AAP36037 DA900348 NM_032588 NP_115977
|
| Function |
E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti- hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells. {ECO:0000269|PubMed:11927605, ECO:0000269|PubMed:18222470}.
|
| Subcellular Location |
Cytoplasm. Nucleus {ECO:0000250}. Cytoplasm, myofibril, sarcomere, M line. Cytoplasm, myofibril, sarcomere, Z line. Note=Colocalizes with TNNI3 in myocytes (By similarity). Localizes to the M- and Z-lines in skeletal muscle. {ECO:0000250}.
|
| Tissue Specificity |
Muscle specific. Selectively expressed in heart and skeletal muscle. Also expressed in the iris. {ECO:0000269|PubMed:11243782, ECO:0000269|PubMed:11283016, ECO:0000269|PubMed:11679633, ECO:0000269|PubMed:12107412}.
|