TRIM63

Gene Symbol	TRIM63
Entrez Gene	84676
Alt Symbol	IRF, MURF1, MURF2, RNF28, SMRZ
Species	Human
Gene Type	protein-coding
Description	tripartite motif containing 63, E3 ubiquitin protein ligase
Other Description	E3 ubiquitin-protein ligase TRIM63|iris ring finger protein|muscle specific ring finger protein 2|muscle-specific RING finger protein 1|ring finger protein 28|striated muscle RING zinc finger protein|tripartite motif-containing protein 63
Swissprots	Q9BYV4 B4DN95 Q96KD9 Q5T2I1 Q969Q1 Q96BD3
Accessions	EAX07848 Q969Q1 AF353673 AAK39519 AF361946 AAK52497 AI351421 AJ276484 CAC81706 AK056942 BAB71318 AK297820 BAG60157 BC080529 AAH80529 BT007373 AAP36037 DA900348 NM_032588 NP_115977
Function	E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti- hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells. {ECO:0000269|PubMed:11927605, ECO:0000269|PubMed:18222470}.
Subcellular Location	Cytoplasm. Nucleus {ECO:0000250}. Cytoplasm, myofibril, sarcomere, M line. Cytoplasm, myofibril, sarcomere, Z line. Note=Colocalizes with TNNI3 in myocytes (By similarity). Localizes to the M- and Z-lines in skeletal muscle. {ECO:0000250}.
Tissue Specificity	Muscle specific. Selectively expressed in heart and skeletal muscle. Also expressed in the iris. {ECO:0000269|PubMed:11243782, ECO:0000269|PubMed:11283016, ECO:0000269|PubMed:11679633, ECO:0000269|PubMed:12107412}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human MURF1 full length protein - ab125750 from Abcam Category Protein Prices $195.00 Sizes 25 µg Source E. coli Species Human

Active human MURF1 full length protein - ab188731 from Abcam Category Protein Prices $629.00 Sizes 25 µg Source E. coli Species Human

Human MURF1 peptide - ab87125 from Abcam Category Peptide

Human MURF1 peptide - ab22986 from Abcam Category Peptide Species Human

Human MURF1 protein fragment - ab112428 from Abcam Category Protein Source Wheat germ Species Human

MURF1 / IRF Antibody Blocking Peptide - LS-E25509 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MURF1 / IRF Antibody Blocking Peptide - LS-E15953 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MURF1 / IRF Antibody Blocking Peptide - LS-E26002 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human MuRF1/TRIM63 Protein - H00084676-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human MuRF1/TRIM63 Protein - H00084676-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

MuRF1/TRIM63 Peptide - NBP2-11063 from Novus Biologicals Category Peptide Prices $249.00 Sizes 250 µg

TRIM63-Antibody-Center-Blocking-Peptide - BP19533c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MURF1 (internal) blocking peptide - GTX89466-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat, Bovine

MURF1 (N Term) blocking peptide - GTX89853-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Dog, Bovine

Recombinant Human His6-MuRF1/TRIM63, CF - E3-100-025 from R&D Systems Category Protein Source E. coli-derived, Contains an N-terminal 6-His tag

TRIM63 Blocking Peptide - 33R-2669 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

MURF1 Peptide - AC21-0337-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

MURF1 Peptide - AC21-0830-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

TRIM63 / MURF1 / RNF28 - H00084676-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

TRIM63 / MURF1 / RNF28 - H00084676-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

TRIM63 / MURF1 / RNF28 - H00084676-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

TRIM63 / MURF1 / RNF28 - H00084676-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

MURF1 Peptide - 45-918P from ProSci Category Peptide Prices $175.00 Sizes 100 µg

MURF1 Peptide - 45-917P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

Recombinant Human TRIM63 - TRIM63-30260TH from Creative Biomart Category Protein Source Wheat germ

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