TRIM63

Gene Symbol	TRIM63
Entrez Gene	84676
Alt Symbol	IRF, MURF1, MURF2, RNF28, SMRZ
Species	Human
Gene Type	protein-coding
Description	tripartite motif containing 63, E3 ubiquitin protein ligase
Other Description	E3 ubiquitin-protein ligase TRIM63|iris ring finger protein|muscle specific ring finger protein 2|muscle-specific RING finger protein 1|ring finger protein 28|striated muscle RING zinc finger protein|tripartite motif-containing protein 63
Swissprots	Q9BYV4 B4DN95 Q96KD9 Q5T2I1 Q969Q1 Q96BD3
Accessions	EAX07848 Q969Q1 AF353673 AAK39519 AF361946 AAK52497 AI351421 AJ276484 CAC81706 AK056942 BAB71318 AK297820 BAG60157 BC080529 AAH80529 BT007373 AAP36037 DA900348 NM_032588 NP_115977
Function	E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti- hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells. {ECO:0000269|PubMed:11927605, ECO:0000269|PubMed:18222470}.
Subcellular Location	Cytoplasm. Nucleus {ECO:0000250}. Cytoplasm, myofibril, sarcomere, M line. Cytoplasm, myofibril, sarcomere, Z line. Note=Colocalizes with TNNI3 in myocytes (By similarity). Localizes to the M- and Z-lines in skeletal muscle. {ECO:0000250}.
Tissue Specificity	Muscle specific. Selectively expressed in heart and skeletal muscle. Also expressed in the iris. {ECO:0000269|PubMed:11243782, ECO:0000269|PubMed:11283016, ECO:0000269|PubMed:11679633, ECO:0000269|PubMed:12107412}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

MuRF1 CRISPR/Cas9 KO Plasmid (h) - sc-400797 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

MuRF1 HDR Plasmid (h) - sc-400797-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

MuRF1 Double Nickase Plasmid (h) - sc-400797-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

MuRF1 Double Nickase Plasmid (h2) - sc-400797-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

MuRF1 CRISPR Activation Plasmid (h) - sc-400797-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

MuRF1 CRISPR Activation Plasmid (h2) - sc-400797-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

MuRF1 Lentiviral Activation Particles (h) - sc-400797-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

MuRF1 Lentiviral Activation Particles (h2) - sc-400797-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

MuRF1 siRNA (h) - sc-43951 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MuRF1 shRNA Plasmid (h) - sc-43951-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MuRF1 shRNA (h) Lentiviral Particles - sc-43951-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MuRF1/TRIM63 RNAi - H00084676-R01V from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MuRF1/TRIM63 RNAi - H00084676-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU019021 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN22005 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22005 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR04562 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr04562

TRIM63 siRNA (Human) - CRJ3574 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

TRIM63 - MBS8233471 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

MuRF1 CRISPR/Cas9 KO Plasmid (h2) - sc-400797-KO-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

MuRF1 HDR Plasmid (h2) - sc-400797-HDR-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

shRNA set against Human TRIM63 (NM_032588.3) - SHH434980 from Creative biogene Category siRNA Species Reactivities Human

Human TRIM63 siRNA - orb274075 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

TRIM63 shRNA Plasmid (Human) - CHJ3574 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

TRIM63 miRNA 3'UTR clone - MiUTR4H-TG09371 from Creative biogene Species Reactivities Human

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