| Gene Symbol |
TRIM11
|
| Entrez Gene |
81559
|
| Alt Symbol |
BIA1, RNF92
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
tripartite motif containing 11
|
| Other Description |
E3 ubiquitin-protein ligase TRIM11|RING finger protein 92|tripartite motif-containing 11|tripartite motif-containing protein 11
|
| Swissprots |
B3KUS3 Q8NCA6 Q96F44 Q9C022 Q5VSU1 B4DX88 A6NKE2 B2RB82
|
| Accessions |
EAW69871 Q96F44 AF220125 AAG53498 AF327056 AAM63957 AK074866 BAC11254 AK097825 BAG53535 AK226119 AK301859 BAG63300 AK314539 BAG37129 AL360165 BC011629 AAH11629 BC069227 AAH69227 EU447015 ABZ92544 XM_011544285 XP_011542587 NM_145214 NP_660215
|
| Function |
E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses. Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression. Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain. May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction
|
| Subcellular Location |
Cytoplasm. Nucleus.
|
| Tissue Specificity |
Ubiquitous.
|